<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE202236" accession="SRP373640">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP373640</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA835100</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE202236</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Dorsal hippocampal transcriptome analysis after Auditory Fear Conditioning and pharmacological GR modulation</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>Aim: We investigated the role of GR in Auditory Fear Conditioning memory consolidation by application of a pharmacological filter using selective glucocorticoid receptor modulators. Methods: Adult male mice were exposed to Auditory Fear Conditioning training and subsequently injected with 3.0 mg/kg corticosterone, 20 mg/kg CORT108297, 80 mg/kg CORT118335, 40 mg/kg RU486 or vehicle. Dorsal hippocampi were dissected 3 hours after injection and snap-frozen. Total RNA was isolated and send for 100bp paired-end sequencing by BGI. Overall design: Hippocampal mRNA profiles of male mice after Auditory Fear Conditioning combined with multiple GR-ligands.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE202236</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
  </STUDY>
</STUDY_SET>
