SRX15156434 GSM6106869_r1 SRP373655 PRJNA835108 SRS12898984 GSM6106869 GSM6106869 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156435 GSM6106870_r1 SRP373655 PRJNA835108 SRS12898985 GSM6106870 GSM6106870 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156436 GSM6106871_r1 SRP373655 PRJNA835108 SRS12898986 GSM6106871 GSM6106871 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156437 GSM6106872_r1 SRP373655 PRJNA835108 SRS12898987 GSM6106872 GSM6106872 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156438 GSM6106873_r1 SRP373655 PRJNA835108 SRS12898988 GSM6106873 GSM6106873 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156439 GSM6106874_r1 SRP373655 PRJNA835108 SRS12898989 GSM6106874 GSM6106874 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156440 GSM6106875_r1 SRP373655 PRJNA835108 SRS12898990 GSM6106875 GSM6106875 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156441 GSM6106876_r1 SRP373655 PRJNA835108 SRS12898991 GSM6106876 GSM6106876 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156442 GSM6106877_r1 SRP373655 PRJNA835108 SRS12898992 GSM6106877 GSM6106877 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156443 GSM6106878_r1 SRP373655 PRJNA835108 SRS12898993 GSM6106878 GSM6106878 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156444 GSM6106879_r1 SRP373655 PRJNA835108 SRS12898994 GSM6106879 GSM6106879 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156445 GSM6106880_r1 SRP373655 PRJNA835108 SRS12898995 GSM6106880 GSM6106880 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156446 GSM6106881_r1 SRP373655 PRJNA835108 SRS12898996 GSM6106881 GSM6106881 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156447 GSM6106882_r1 SRP373655 PRJNA835108 SRS12898997 GSM6106882 GSM6106882 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156448 GSM6106883_r1 SRP373655 PRJNA835108 SRS12898998 GSM6106883 GSM6106883 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156449 GSM6106884_r1 SRP373655 PRJNA835108 SRS12898999 GSM6106884 GSM6106884 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156450 GSM6106885_r1 SRP373655 PRJNA835108 SRS12899000 GSM6106885 GSM6106885 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156451 GSM6106886_r1 SRP373655 PRJNA835108 SRS12899001 GSM6106886 GSM6106886 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156452 GSM6106887_r1 SRP373655 PRJNA835108 SRS12899002 GSM6106887 GSM6106887 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156453 GSM6106888_r1 SRP373655 PRJNA835108 SRS12899003 GSM6106888 GSM6106888 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156454 GSM6106889_r1 SRP373655 PRJNA835108 SRS12899004 GSM6106889 GSM6106889 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156455 GSM6106890_r1 SRP373655 PRJNA835108 SRS12899005 GSM6106890 GSM6106890 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156456 GSM6106891_r1 SRP373655 PRJNA835108 SRS12899006 GSM6106891 GSM6106891 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156457 GSM6106892_r1 SRP373655 PRJNA835108 SRS12899007 GSM6106892 GSM6106892 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156458 GSM6106893_r1 SRP373655 PRJNA835108 SRS12899008 GSM6106893 GSM6106893 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156459 GSM6106894_r1 SRP373655 PRJNA835108 SRS12899009 GSM6106894 GSM6106894 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156460 GSM6106895_r1 SRP373655 PRJNA835108 SRS12899010 GSM6106895 GSM6106895 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156461 GSM6106896_r1 SRP373655 PRJNA835108 SRS12899011 GSM6106896 GSM6106896 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156462 GSM6106897_r1 SRP373655 PRJNA835108 SRS12899012 GSM6106897 GSM6106897 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156463 GSM6106898_r1 SRP373655 PRJNA835108 SRS12899013 GSM6106898 GSM6106898 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156464 GSM6106899_r1 SRP373655 PRJNA835108 SRS12899014 GSM6106899 GSM6106899 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156465 GSM6106900_r1 SRP373655 PRJNA835108 SRS12899015 GSM6106900 GSM6106900 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156466 GSM6106901_r1 SRP373655 PRJNA835108 SRS12899016 GSM6106901 GSM6106901 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156467 GSM6106902_r1 SRP373655 PRJNA835108 SRS12899017 GSM6106902 GSM6106902 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156468 GSM6106903_r1 SRP373655 PRJNA835108 SRS12899018 GSM6106903 GSM6106903 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000 SRX15156469 GSM6106904_r1 SRP373655 PRJNA835108 SRS12899019 GSM6106904 GSM6106904 ChIP-Seq GENOMIC ChIP Cells were fixed with 1% formaldehyde. Cultured cells were lysed, and the DNA was sheared to 100- to 300-bp fragments. Histone-bound DNA was precipitated using antibodies against H3K27ac (ab4729, Abcam). Cross-linking was reversed, and DNA was purified using the Qiagen PCR purification kit (Qiagen) and quantified with Qubit HS assay kit (Invitrogen). The DNA was used to generate sequencing libraries according to the manufacturer's procedure (NEBNext® Ultra™ II DNA Library Prep Kit for Illumina). The DNA was end polished and dA tailed, and adaptors with barcodes were ligated. The fragments were amplified and quantified with KAPA quantification kit (Roche) and the library size was determined using tape station (Agilent). Libraries were sequenced on NovaSeq (Illumina), using SP-flow cell resulting in 150-bp paired-end reads. Illumina NovaSeq 6000