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<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT accession="SRX15209851" alias="GSM6123698_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209851</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123698_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123698: Minus1-to-1 randomization AQ-seq with let-7a-1 10% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948372">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948372</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123698</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123698</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209852" alias="GSM6123699_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209852</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123699_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123699: Minus1-to-1 randomization AQ-seq with let-7a-1 20% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948373">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948373</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123699</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123699</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209853" alias="GSM6123700_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209853</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123700_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123700: Minus1-to-1 randomization AQ-seq with let-7a-1 30% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948374">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948374</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123700</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123700</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209854" alias="GSM6123701_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209854</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123701_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123701: Minus1-to-1 randomization AQ-seq with miR-374b input; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948375">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948375</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123701</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123701</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209855" alias="GSM6123702_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209855</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123702_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123702: Minus1-to-1 randomization AQ-seq with miR-374b 10% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948376">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948376</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123702</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123702</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209856" alias="GSM6123703_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209856</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123703_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123703: Minus1-to-1 randomization AQ-seq with miR-374b 20% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948377">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948377</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123703</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123703</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209857" alias="GSM6123704_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209857</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123704_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123704: Minus1-to-1 randomization AQ-seq with miR-374b 30% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948378">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948378</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123704</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123704</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209858" alias="GSM6123705_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209858</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123705_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123705: 1-to-3 randomization AQ-seq with let-7a-1 input; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948379">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948379</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123705</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123705</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209859" alias="GSM6123706_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209859</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123706_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123706: 1-to-3 randomization AQ-seq with let-7a-1 10% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948380">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948380</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123706</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123706</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209860" alias="GSM6123707_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209860</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123707_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123707: 1-to-3 randomization AQ-seq with let-7a-1 20% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948381">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948381</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123707</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123707</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209861" alias="GSM6123708_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209861</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123708_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123708: 1-to-3 randomization AQ-seq with let-7a-1 30% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948382">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948382</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123708</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123708</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209862" alias="GSM6123709_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209862</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123709_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123709: 1-to-3 randomization AQ-seq with miR-374b input; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948383">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948383</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123709</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123709</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209863" alias="GSM6123710_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209863</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123710_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123710: 1-to-3 randomization AQ-seq with miR-374b 10% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948384">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948384</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123710</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123710</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209864" alias="GSM6123711_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209864</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123711_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123711: 1-to-3 randomization AQ-seq with miR-374b 20% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948385">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948385</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123711</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123711</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209865" alias="GSM6123712_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209865</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123712_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123712: 1-to-3 randomization AQ-seq with miR-374b 30% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948386">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948386</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123712</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123712</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209866" alias="GSM6123695_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209866</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123695_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123695: Minus1-to-3 randomization AQ-seq with let-7a-1 input; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948387">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948387</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123695</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123695</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209867" alias="GSM6123696_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209867</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123696_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123696: Minus1-to-3 randomization AQ-seq with let-7a-1 5% cleavage; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948388">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948388</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123696</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123696</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX15209868" alias="GSM6123697_r1">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX15209868</PRIMARY_ID>
      <EXTERNAL_ID namespace="GEO">GSM6123697_r1</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>GSM6123697: Minus1-to-1 randomization AQ-seq with let-7a-1 input; Homo sapiens; miRNA-Seq</TITLE>
    <STUDY_REF accession="SRP374309">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP374309</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA836500</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS12948389">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS12948389</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM6123697</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>GSM6123697</LIBRARY_NAME>
        <LIBRARY_STRATEGY>miRNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>size fractionation</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Gel purification The input and uncleaved pre-miRNAs were subjected to AQ-seq as previously described (Kim et al., 2019), with some modifications as follows. After 3′ adapter ligation, the ligated RNAs were purified on a 10% urea-polyacrylamide gel along with Century-Plus RNA Markers (Thermo Fisher) as a size marker. After reverse transcription, cDNAs were amplified with NEBNext Ultra II Q5 Master Mix (NEB). The libraries were sequenced on the NovaSeq 6000 platform.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina NovaSeq 6000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
</EXPERIMENT_SET>
