SRX15212864 GSM6124422_r1 SRP374372 PRJNA836563 SRS12950470 GSM6124422 GSM6124422 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212865 GSM6124423_r1 SRP374372 PRJNA836563 SRS12950471 GSM6124423 GSM6124423 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212866 GSM6124424_r1 SRP374372 PRJNA836563 SRS12950472 GSM6124424 GSM6124424 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212867 GSM6124425_r1 SRP374372 PRJNA836563 SRS12950473 GSM6124425 GSM6124425 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212868 GSM6124426_r1 SRP374372 PRJNA836563 SRS12950474 GSM6124426 GSM6124426 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212869 GSM6124427_r1 SRP374372 PRJNA836563 SRS12950475 GSM6124427 GSM6124427 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212870 GSM6124428_r1 SRP374372 PRJNA836563 SRS12950476 GSM6124428 GSM6124428 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212871 GSM6124429_r1 SRP374372 PRJNA836563 SRS12950477 GSM6124429 GSM6124429 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212872 GSM6124430_r1 SRP374372 PRJNA836563 SRS12950478 GSM6124430 GSM6124430 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212873 GSM6124431_r1 SRP374372 PRJNA836563 SRS12950479 GSM6124431 GSM6124431 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212874 GSM6124432_r1 SRP374372 PRJNA836563 SRS12950480 GSM6124432 GSM6124432 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212875 GSM6124433_r1 SRP374372 PRJNA836563 SRS12950481 GSM6124433 GSM6124433 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000 SRX15212876 GSM6124434_r1 SRP374372 PRJNA836563 SRS12950482 GSM6124434 GSM6124434 ncRNA-Seq TRANSCRIPTOMIC size fractionation For small RNA-seq profiling, the plasma exosome RNA was purified from 13 subjects, respectively. The exosome RNA was isolated from plasma exosome using the RNA isolation reagent TRIzol (Invitrogen). By using the QIAseq® miRNA Library Kit (QIAgen, Cat# 331505), small RNA-seq libraries were constructed with 2~10 ng of the prepared exosomal small RNA in line with the manufacturer's protocols. Small RNA-seq libraries were prepared according to Illumina's instructions and sequenced on an Illumina 3000 analyzer by EPIBIOTEK Company (Guangzhou, China). Illumina HiSeq 3000