SRX15231489 GSM6131580_r1 SRP374660 PRJNA837078 SRS12964939 GSM6131580 GSM6131580 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231490 GSM6131582_r1 SRP374660 PRJNA837078 SRS12964940 GSM6131582 GSM6131582 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231491 GSM6131583_r1 SRP374660 PRJNA837078 SRS12964941 GSM6131583 GSM6131583 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231492 GSM6131585_r1 SRP374660 PRJNA837078 SRS12964942 GSM6131585 GSM6131585 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231493 GSM6131586_r1 SRP374660 PRJNA837078 SRS12964943 GSM6131586 GSM6131586 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231494 GSM6131588_r1 SRP374660 PRJNA837078 SRS12964944 GSM6131588 GSM6131588 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231495 GSM6131589_r1 SRP374660 PRJNA837078 SRS12964945 GSM6131589 GSM6131589 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231496 GSM6131591_r1 SRP374660 PRJNA837078 SRS12964946 GSM6131591 GSM6131591 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231497 GSM6131587_r1 SRP374660 PRJNA837078 SRS12964947 GSM6131587 GSM6131587 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231498 GSM6131584_r1 SRP374660 PRJNA837078 SRS12964948 GSM6131584 GSM6131584 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231499 GSM6131581_r1 SRP374660 PRJNA837078 SRS12964949 GSM6131581 GSM6131581 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000 SRX15231500 GSM6131590_r1 SRP374660 PRJNA837078 SRS12964950 GSM6131590 GSM6131590 OTHER GENOMIC other Cells were permeablized with 0.02% digitonin. CUT&RUN fragments were extracted following the protocol based on Skene&Henikoff, Nat Protoc. 2018. and resuspended in 13 µL of H2O. CUT&RUN libraries were prepared with Takara ThruPLEX DNA-Seq Kit and barcoded with Takara DNA Unique Dual Index Kit. 10 µL of input material was used for library preparation. The libraries were then amplified with 16 cycles of 98° C for 15 s and 60° C for 10 s on thermocycler to allow prefrential amplification of the small CUT&RUN fragments. Libraries were then purified with AMPure XP beads and validated on Agilent TapeStation. NextSeq 2000