<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE202866" accession="SRP374951">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP374951</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA837565</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE202866</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Trancriptomic characterization of labetuzumab effect on IL13-treated human bronchial epithelial cells</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>We have characterized the effect of the CEACAM5 targeting monoclonal antibody labetuzumab (2 µg/mL) on the transcriptional response to interleukin-13 (IL-13) treatment (10ng/mL) of air-liquid interface (ALI) cultures generated from primary human bronchial epithelial cells. ALI cultures were treated with IL-13 and labetuzumab during the last 7 days of ALI development and the transcriptomes analyzed by RNA-seq. Overall design: We analyzed the transcriptomes of 12 ALI cultures divided in 3 experimental groups: untreated control ALIs ( no IL-13, no labetuzumab), IL-13 treated ALIs and ALIs treated with both IL-13 and labetuzumab.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE202866</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
  </STUDY>
</STUDY_SET>
