SRP384410 PRJNA854654 GSE207295 BET inhibition induces synthetic lethality in BRCA2-deficient pancreatic cancer via autophagy-dependent cell death [RNA-Seq] To model familial pancreatic cancer patients, we generated isogenic Brca2 deficient pancreatic cancer cell lines with CRISPR/Cas9. To investigate the changes in the transcriptome profiles upon BET inhibition, we performed RNA-seq. Overall design: Upon JQ1 treatment (1 µM) for 72 hrs, the control and Brca2 KO KPC cells were subjected to RNA-seq experiments. GSE207295 pubmed 37735513 parent_bioproject PRJNA854647