SRX17232228 GSM6510099_r1 SRP394178 PRJNA874089 SRS14798544 GSM6510099 GSM6510099 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232229 GSM6510100_r1 SRP394178 PRJNA874089 SRS14798545 GSM6510100 GSM6510100 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232230 GSM6510101_r1 SRP394178 PRJNA874089 SRS14798546 GSM6510101 GSM6510101 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232231 GSM6510102_r1 SRP394178 PRJNA874089 SRS14798547 GSM6510102 GSM6510102 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232232 GSM6510103_r1 SRP394178 PRJNA874089 SRS14798548 GSM6510103 GSM6510103 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232233 GSM6510104_r1 SRP394178 PRJNA874089 SRS14798549 GSM6510104 GSM6510104 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232234 GSM6510105_r1 SRP394178 PRJNA874089 SRS14798550 GSM6510105 GSM6510105 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232235 GSM6510106_r1 SRP394178 PRJNA874089 SRS14798551 GSM6510106 GSM6510106 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232236 GSM6510107_r1 SRP394178 PRJNA874089 SRS14798552 GSM6510107 GSM6510107 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232237 GSM6510108_r1 SRP394178 PRJNA874089 SRS14798553 GSM6510108 GSM6510108 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232238 GSM6510109_r1 SRP394178 PRJNA874089 SRS14798554 GSM6510109 GSM6510109 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232239 GSM6510110_r1 SRP394178 PRJNA874089 SRS14798555 GSM6510110 GSM6510110 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232240 GSM6510111_r1 SRP394178 PRJNA874089 SRS14798556 GSM6510111 GSM6510111 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232241 GSM6510112_r1 SRP394178 PRJNA874089 SRS14798557 GSM6510112 GSM6510112 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232242 GSM6510113_r1 SRP394178 PRJNA874089 SRS14798558 GSM6510113 GSM6510113 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232243 GSM6510114_r1 SRP394178 PRJNA874089 SRS14798559 GSM6510114 GSM6510114 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232244 GSM6510115_r1 SRP394178 PRJNA874089 SRS14798560 GSM6510115 GSM6510115 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232245 GSM6510116_r1 SRP394178 PRJNA874089 SRS14798561 GSM6510116 GSM6510116 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232246 GSM6510117_r1 SRP394178 PRJNA874089 SRS14798562 GSM6510117 GSM6510117 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232247 GSM6510118_r1 SRP394178 PRJNA874089 SRS14798563 GSM6510118 GSM6510118 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232248 GSM6510119_r1 SRP394178 PRJNA874089 SRS14798564 GSM6510119 GSM6510119 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232249 GSM6510120_r1 SRP394178 PRJNA874089 SRS14798565 GSM6510120 GSM6510120 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232250 GSM6510121_r1 SRP394178 PRJNA874089 SRS14798566 GSM6510121 GSM6510121 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232251 GSM6510122_r1 SRP394178 PRJNA874089 SRS14798567 GSM6510122 GSM6510122 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232252 GSM6510123_r1 SRP394178 PRJNA874089 SRS14798568 GSM6510123 GSM6510123 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232253 GSM6510124_r1 SRP394178 PRJNA874089 SRS14798569 GSM6510124 GSM6510124 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232254 GSM6510125_r1 SRP394178 PRJNA874089 SRS14798570 GSM6510125 GSM6510125 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232255 GSM6510126_r1 SRP394178 PRJNA874089 SRS14798571 GSM6510126 GSM6510126 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500 SRX17232256 GSM6510127_r1 SRP394178 PRJNA874089 SRS14798572 GSM6510127 GSM6510127 RNA-Seq TRANSCRIPTOMIC cDNA Fresh right lungs were immediately collected in RNAlater™ (Sigma, USA) for the next homogenization in QIAzol® Lysis Reagent (QIAGEN, Netherlands) with gentleMACS™ Dissociator (Miltenyi Biotec, Germany). RNA was extracted using the QIAcube robotic workstation with the miRNeasy Mini Kit (QIAGEN, Netherlands), including DNase digestion protocol. Libraries for massive parallel RNA sequencing (RNA-seq) were prepared with the QuantSeq 3' mRNA-Seq Library Prep Kit FWD (Lexogen) and sequenced, in two runs, with the use of an Illumina NextSeq500 platform, which generated at least 30 million reads/sample (75 bp Single End). NextSeq 500