SRX17916313 GSM6647585_r1 SRP403047 PRJNA891303 SRS15431965 GSM6647585 GSM6647585 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916314 GSM6647586_r1 SRP403047 PRJNA891303 SRS15431964 GSM6647586 GSM6647586 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916315 GSM6647587_r1 SRP403047 PRJNA891303 SRS15431966 GSM6647587 GSM6647587 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916316 GSM6647588_r1 SRP403047 PRJNA891303 SRS15431967 GSM6647588 GSM6647588 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916317 GSM6647589_r1 SRP403047 PRJNA891303 SRS15431968 GSM6647589 GSM6647589 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916318 GSM6647590_r1 SRP403047 PRJNA891303 SRS15431969 GSM6647590 GSM6647590 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916319 GSM6647591_r1 SRP403047 PRJNA891303 SRS15431970 GSM6647591 GSM6647591 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq SRX17916320 GSM6647592_r1 SRP403047 PRJNA891303 SRS15431971 GSM6647592 GSM6647592 OTHER TRANSCRIPTOMIC other Qiagen RNAeasy micro kit miLaboratory Human TCR profiling kit. Liver biopsies were obtained in RNAlater and transferred into 2ml tubes containing 600µl RLT+ buffer + 1% -Mercaptoethanol. Tissue was disrupted using the Qiagen tissue lyser. PBMCs were isolated from paired blood samples by density gradient centrifugation (Biocoll; Biochrom, Berlin, Germany) and CD4+ T cells were enriched using CD4 Microbeads (Miltenyi Biotec). RNA was isolated from liver samples and CD4+ T cells from PBMCs using the RNeasy Micro Kit (Qiagen). TCR libraries were prepared using human TCR RNA multiplex kit (MiLaboratories), according to the manufacturer's protocol using 24 PCR cycles (liver) and 18 PCR cycles (blood) for the 1st PCR, and 14 PCR cycles (liver) and 16 PCR cycles (blood) for the 2nd PCR amplification. Libraries were sequenced on an Illumina NovaSeq6000 machine, SP v1.5 flow cells and 300 cycles. Data of both TCRα and β chains were obtained. Illumina MiSeq