SRX17977893 GSM6664636_r1 SRP403777 PRJNA892651 SRS15493129 GSM6664636 GSM6664636 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977894 GSM6664637_r1 SRP403777 PRJNA892651 SRS15493130 GSM6664637 GSM6664637 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977895 GSM6664638_r1 SRP403777 PRJNA892651 SRS15493131 GSM6664638 GSM6664638 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977896 GSM6664639_r1 SRP403777 PRJNA892651 SRS15493132 GSM6664639 GSM6664639 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977897 GSM6664640_r1 SRP403777 PRJNA892651 SRS15493133 GSM6664640 GSM6664640 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977898 GSM6664641_r1 SRP403777 PRJNA892651 SRS15493134 GSM6664641 GSM6664641 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977899 GSM6664642_r1 SRP403777 PRJNA892651 SRS15493135 GSM6664642 GSM6664642 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977900 GSM6664643_r1 SRP403777 PRJNA892651 SRS15493136 GSM6664643 GSM6664643 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977901 GSM6664644_r1 SRP403777 PRJNA892651 SRS15493137 GSM6664644 GSM6664644 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977902 GSM6664645_r1 SRP403777 PRJNA892651 SRS15493138 GSM6664645 GSM6664645 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977903 GSM6664646_r1 SRP403777 PRJNA892651 SRS15493139 GSM6664646 GSM6664646 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977904 GSM6664647_r1 SRP403777 PRJNA892651 SRS15493140 GSM6664647 GSM6664647 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977905 GSM6664648_r1 SRP403777 PRJNA892651 SRS15493141 GSM6664648 GSM6664648 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977906 GSM6664649_r1 SRP403777 PRJNA892651 SRS15493142 GSM6664649 GSM6664649 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977907 GSM6664650_r1 SRP403777 PRJNA892651 SRS15493143 GSM6664650 GSM6664650 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977908 GSM6664651_r1 SRP403777 PRJNA892651 SRS15493144 GSM6664651 GSM6664651 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977909 GSM6664668_r1 SRP403777 PRJNA892651 SRS15493145 GSM6664668 GSM6664668 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977910 GSM6664652_r1 SRP403777 PRJNA892651 SRS15493146 GSM6664652 GSM6664652 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977911 GSM6664653_r1 SRP403777 PRJNA892651 SRS15493147 GSM6664653 GSM6664653 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977912 GSM6664654_r1 SRP403777 PRJNA892651 SRS15493148 GSM6664654 GSM6664654 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977913 GSM6664655_r1 SRP403777 PRJNA892651 SRS15493149 GSM6664655 GSM6664655 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977914 GSM6664656_r1 SRP403777 PRJNA892651 SRS15493150 GSM6664656 GSM6664656 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977915 GSM6664657_r1 SRP403777 PRJNA892651 SRS15493151 GSM6664657 GSM6664657 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977916 GSM6664658_r1 SRP403777 PRJNA892651 SRS15493152 GSM6664658 GSM6664658 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977917 GSM6664659_r1 SRP403777 PRJNA892651 SRS15493153 GSM6664659 GSM6664659 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977918 GSM6664660_r1 SRP403777 PRJNA892651 SRS15493154 GSM6664660 GSM6664660 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977919 GSM6664661_r1 SRP403777 PRJNA892651 SRS15493155 GSM6664661 GSM6664661 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977920 GSM6664662_r1 SRP403777 PRJNA892651 SRS15493156 GSM6664662 GSM6664662 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977921 GSM6664663_r1 SRP403777 PRJNA892651 SRS15493157 GSM6664663 GSM6664663 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977922 GSM6664664_r1 SRP403777 PRJNA892651 SRS15493158 GSM6664664 GSM6664664 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977923 GSM6664665_r1 SRP403777 PRJNA892651 SRS15493159 GSM6664665 GSM6664665 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977924 GSM6664666_r1 SRP403777 PRJNA892651 SRS15493160 GSM6664666 GSM6664666 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000 SRX17977925 GSM6664667_r1 SRP403777 PRJNA892651 SRS15493161 GSM6664667 GSM6664667 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated at 12-24 hours after editing using RNeasy Micro Kit (QIAGEN), and DNase treatment was performed using RNase-free DNase Set (QIAGEN), according to the manufacturer's instructions. RNA was quantified with The Qubit 2.0 Fluorometer (Thermo Fisher) and its quality was assessed by a 2100 Agilent Bioanalyser (Agilent Technologies). Minimum quality was defined as RNA integrity number (RIN) of >8. 20-100 ng of total RNA were used for library preparation and subsequent ultra-low input or standard sequencing by Genewiz (Azenta Life Sciences). Illumina NovaSeq 6000