SRP404608 PRJNA894501 GSE216610 P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway We used RNA sequencing to deciphere a molecular basis for the synthethic lethality of non-genotoxic p53 activation and P-TEFb inhibition. Overall design: We treated HCT116 cell line in biological triplicates with DMSO, Nutlin-3a (10 uM), NVP-2 (20 nM), and Nutlin-3a (10 uM) together with NVP-2 (20 nM) for 8 hours. GSE216610 pubmed 36727434