SRX18044882 GSM6685996_r1 SRP404855 PRJNA894970 SRS15551414 GSM6685996 GSM6685996 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044883 GSM6685997_r1 SRP404855 PRJNA894970 SRS15551413 GSM6685997 GSM6685997 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044884 GSM6685998_r1 SRP404855 PRJNA894970 SRS15551415 GSM6685998 GSM6685998 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044885 GSM6685999_r1 SRP404855 PRJNA894970 SRS15551416 GSM6685999 GSM6685999 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044886 GSM6686000_r1 SRP404855 PRJNA894970 SRS15551417 GSM6686000 GSM6686000 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044887 GSM6686001_r1 SRP404855 PRJNA894970 SRS15551418 GSM6686001 GSM6686001 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044888 GSM6686002_r1 SRP404855 PRJNA894970 SRS15551419 GSM6686002 GSM6686002 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000 SRX18044889 GSM6686003_r1 SRP404855 PRJNA894970 SRS15551420 GSM6686003 GSM6686003 RNA-Seq TRANSCRIPTOMIC cDNA Peripheral blood samples were obtained from healthy adult volunteers. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation using Lymphoprep (Axis-Shield, Oslo, Norway). CD4+ T-cells were isolated by magnetic-activated cell sorting (MACS) using the CD4+ T-cell Isolation Kit II (Miltenyi Biotec, Bergisch-Gladbach, Germany). RNA was isolated using RNeasy Mini kit (Qiagen) following manufacturer's instructions. cDNA synthesis and amplification were performed using a NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (NEB, Massachuestts, USA) following the manufacturer's protocol. Dual-indexed libraries were prepared using the NEBNext® Multiplex Oligos for Illumina® (Dual Index Primers Set 1) following the manufacturer's protocol. Illumina NovaSeq 6000