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    <TITLE>patient 3 bronchoalveolar lavage</TITLE>
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      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 5 bronchoalveolar lavage</TITLE>
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      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 10 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 3 bronchial aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
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      <PRIMARY_ID>SRX18271607</PRIMARY_ID>
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    <TITLE>patient 5 bronchial aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 6 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 7 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 8 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 9 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 14 bronchial aspirate</TITLE>
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      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 15 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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    <TITLE>patient 16 bronchial aspirate</TITLE>
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        <PRIMARY_ID>SRP408011</PRIMARY_ID>
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    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
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        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271615" alias="BAL-006_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271615</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-006_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 6 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-006_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271616" alias="BAS23-A_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271616</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAS23-A_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 bronchial aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764872">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764872</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794964</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAS23-A_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271617" alias="BAS-809455_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271617</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAS-809455_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 809455 bronchial aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764872">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764872</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794964</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAS-809455_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271618" alias="BIO_23A_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271618</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO_23A_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO_23A_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271619" alias="BIO-0010_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271619</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-0010_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 10 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-0010_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271620" alias="BIO-0014_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271620</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-0014_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 14 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-0014_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271621" alias="BIO-0015_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271621</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-0015_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 15 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-0015_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271622" alias="BIO-005_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271622</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-005_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 5 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-005_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271623" alias="BIO-006_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271623</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-006_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 6 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-006_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271624" alias="BIO-007_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271624</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-007_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 7 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-007_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271625" alias="BIO-008_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271625</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-008_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 8 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-008_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271626" alias="BAL-007_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271626</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-007_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 7 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-007_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271627" alias="BIO-009_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271627</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-009_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 9 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-009_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271628" alias="BIO-809455_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271628</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BIO-809455_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 809455 biopsy</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764873">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764873</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795340</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BIO-809455_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271629" alias="CEP_0010_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271629</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP_0010_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 10 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP_0010_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271630" alias="CEP_014_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271630</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP_014_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 14 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP_014_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271631" alias="CEP_016.final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271631</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP_016.final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 16 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP_016.final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271632" alias="CEP_23A.final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271632</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP_23A.final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP_23A.final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271633" alias="CEP-003_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271633</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-003_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 3 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-003_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271634" alias="CEP-005_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271634</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-005_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 5 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-005_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271635" alias="CEP-006_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271635</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-006_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 6 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-006_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271636" alias="CEP-007_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271636</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-007_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 7 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-007_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271637" alias="BAL-008_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271637</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-008_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 8 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-008_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271638" alias="CEP-008_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271638</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-008_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 8 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-008_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271639" alias="CEP-009_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271639</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-009_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 9 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-009_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271640" alias="CEP-809455_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271640</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">CEP-809455_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 809455 bronchial brushing</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764874">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764874</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29795004</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>CEP-809455_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271641" alias="ES_0010_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271641</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES_0010_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 10 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES_0010_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271642" alias="ES_014_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271642</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES_014_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 14 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES_014_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271643" alias="ES_016_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271643</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES_016_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 16 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES_016_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271644" alias="ES_23A_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271644</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES_23A_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES_23A_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271645" alias="ES_V1_015_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271645</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES_V1_015_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 15 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES_V1_015_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271646" alias="ES-003_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271646</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-003_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 3 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-003_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271647" alias="ES-004_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271647</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-004_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 4 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-004_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271648" alias="BAL-009_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271648</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-009_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 9 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-009_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271649" alias="ES-005_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271649</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-005_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 5 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-005_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271650" alias="ES-006_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271650</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-006_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 6 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-006_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271651" alias="ES-007_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271651</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-007_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 7 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-007_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271652" alias="ES-008_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271652</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-008_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 8 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-008_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271653" alias="ES-009_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271653</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-009_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 9 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-009_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271654" alias="ES-011_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271654</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-011_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 11 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-011_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271655" alias="ES-013_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271655</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-013_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 13 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-013_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271656" alias="ES-809455_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271656</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">ES-809455_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 809455 sputum</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764875">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764875</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794932</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>ES-809455_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271657" alias="EX_010_S105_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271657</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX_010_S105_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 10 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX_010_S105_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271658" alias="EX_014_S106_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271658</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX_014_S106_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 14 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX_014_S106_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271659" alias="BAL-014_S107_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271659</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-014_S107_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 14 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-014_S107_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271660" alias="EX_015_S107_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271660</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX_015_S107_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 15 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX_015_S107_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271661" alias="EX_016_S108_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271661</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX_016_S108_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 16 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX_016_S108_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271662" alias="EX_23A_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271662</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX_23A_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX_23A_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271663" alias="EX-003_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271663</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-003_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 3 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-003_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271664" alias="EX-004_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271664</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-004_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 4 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-004_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271665" alias="EX-005_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271665</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-005_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 5 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-005_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271666" alias="EX-006_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271666</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-006_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 6 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-006_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271667" alias="EX-007_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271667</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-007_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 7 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-007_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271668" alias="EX-008_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271668</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-008_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 8 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-008_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271669" alias="EX-009_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271669</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-009_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 9 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-009_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271670" alias="BAL-015_S108_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271670</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-015_S108_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 15 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-015_S108_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271671" alias="EX-809455_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271671</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">EX-809455_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 809455 nasopharyngeal aspirate</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764876">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764876</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794949</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>EX-809455_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271672" alias="BAL-016_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271672</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL-016_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 16 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL-016_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
  <EXPERIMENT accession="SRX18271673" alias="BAL23-A_final_R1_001.fastq.gz">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX18271673</PRIMARY_ID>
      <SUBMITTER_ID namespace="SUB11851274">BAL23-A_final_R1_001.fastq.gz</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>patient 23 bronchoalveolar lavage</TITLE>
    <STUDY_REF accession="SRP408011">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP408011</PRIMARY_ID>
        <EXTERNAL_ID namespace="BioProject">PRJNA859796</EXTERNAL_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>16S rRNA Gene Sequencing. 16S rRNA gene libraries were created as described by Caporaso et al. [62], employing primers that amplify the 16S rRNA gene variable region 4 (V4) region of all bacteria and archaea. A mock community and no template control were included. Amplicons were quantified using the KAPA Library Quantification Kit for Illumina Platforms (KR0405, KAPABiosystems, Wilmington, MA), normalized and pooled. Library quality was assessed by Agilent Bioanalyzer chip then the library was prepared for sequencing on the Illumina MiSeq instrument using a MiSeq v3 Reagent kit (2 x 300 bp reads)</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS15764871">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS15764871</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN29794950</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BAL23-A_final_R1_001.fastq.gz</LIBRARY_NAME>
        <LIBRARY_STRATEGY>AMPLICON</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>METAGENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>PCR</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
  </EXPERIMENT>
</EXPERIMENT_SET>
