SRX18278344 FC1245_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina HiSeq 4000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770746 SAMN31743130 FC1245_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina HiSeq 4000 SRX18278345 FC1245_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina HiSeq 4000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770747 SAMN31743131 FC1245_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina HiSeq 4000 SRX18278346 FC1245_TCE5003_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770748 SAMN31743140 FC1245_TCE5003_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278347 FC1245_TCE5003_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770749 SAMN31743141 FC1245_TCE5003_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278348 FC1245_TCE5003_2 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770750 SAMN31743142 FC1245_TCE5003_2 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278349 FC1245_PRMT12e_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770751 SAMN31743143 FC1245_PRMT12e_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278350 FC1245_PRMT12e_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770752 SAMN31743144 FC1245_PRMT12e_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278351 FC1245_PRMT12e_2 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770753 SAMN31743145 FC1245_PRMT12e_2 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278352 FC1245_UBAP2L_KO_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina HiSeq 4000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770754 SAMN31743132 FC1245_UBAP2L_KO_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina HiSeq 4000 SRX18278353 FC1245_UBAP2L_KO_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina HiSeq 4000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770755 SAMN31743133 FC1245_UBAP2L_KO_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina HiSeq 4000 SRX18278354 FC1245_DMSO_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770756 SAMN31743134 FC1245_DMSO_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278355 FC1245_DMSO_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770757 SAMN31743135 FC1245_DMSO_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278356 FC1245_DMSO_2 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770758 SAMN31743136 FC1245_DMSO_2 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278357 FC1245_AMI_0 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770759 SAMN31743137 FC1245_AMI_0 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278358 FC1245_AMI_1 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770760 SAMN31743138 FC1245_AMI_1 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000 SRX18278359 FC1245_AMI_2 SRP296872 PRJNA678286 RNA from FC1245 cells was isolated using Trizol (Invitrogen) and the RNeasy mini kit with on-column DNase digestion (Qiagen). RNA purity was assessed by Agilent 2100 Bioanalyzer. Sequencing libraries were prepared from 100 ng of total RNA using the TruSeq Stranded Total RNA sample preparation kit (Illumina) according to the manufacturer's protocol. Briefly, mRNA was purified, fragmented and used for first- and second-strand cDNA synthesis followed by adenylation of 3 ends. Samples were ligated to unique adaptors and subjected to PCR amplification. Libraries were then validated using the 2100 BioAnalyzer (Agilent), normalized and pooled for sequencing. RNA-Seq libraries prepared from two replicates for each experimental condition were subjected to single-ended sequencing on the Illumina NovaSeq 6000 using barcoded multiplexing and a 90-bp read length. Image analysis and base calling were done with Illumina software. SRS15770761 SAMN31743139 FC1245_AMI_2 RNA-Seq TRANSCRIPTOMIC RANDOM Illumina NovaSeq 6000