SRX18289141 PSN1_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780894 SAMN31743202 PSN1_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289142 PATU8988T_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780895 SAMN31743203 PATU8988T_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289143 KCIMOH1_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780896 SAMN31743204 KCIMOH1_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289144 HUPT4_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780897 SAMN31743205 HUPT4_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289145 Panc0203_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780898 SAMN31743206 Panc0203_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289146 PANC1_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780899 SAMN31743207 PANC1_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289147 MIAPaCa2_1_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780900 SAMN31743208 MIAPaCa2_1_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289148 MIAPaCa2_2_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780901 SAMN31743209 MIAPaCa2_2_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289149 MIAPaCa2_SEdel_1_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780902 SAMN31743210 MIAPaCa2_SEdel_1_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500 SRX18289150 MIAPaCa2_Sedel_2_ATAC SRP296872 PRJNA678286 Nuclei were harvested and ATAC-seq libraries were prepared according to published methods (Buenrostro et al, Nat Methods 10, 1213-1218, 2013). Libraries were sequenced on an Illumina HiSeq2500 using barcoded multiplexing and a paired-end 42 bp length. Reads were aligned using Bowtie2 to GRCh37 and SE peaks were called using HOMERs (Heinz, S. et al. Mol Cell 38, 576-589, 2010) default settings (-style super, Fold change >4, p-value <0.0001). SRS15780903 SAMN31743211 MIAPaCa2_Sedel_2_ATAC ATAC-seq OTHER size fractionation Illumina HiSeq 2500