SRX18333085 GSM6746050_r1 SRP379849 PRJNA848679 SRS15822152 GSM6746050 GSM6746050 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333086 GSM6746051_r1 SRP379849 PRJNA848679 SRS15822151 GSM6746051 GSM6746051 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333087 GSM6746052_r1 SRP379849 PRJNA848679 SRS15822153 GSM6746052 GSM6746052 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333088 GSM6746053_r1 SRP379849 PRJNA848679 SRS15822154 GSM6746053 GSM6746053 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333089 GSM6746054_r1 SRP379849 PRJNA848679 SRS15822155 GSM6746054 GSM6746054 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333090 GSM6746055_r1 SRP379849 PRJNA848679 SRS15822156 GSM6746055 GSM6746055 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333091 GSM6746056_r1 SRP379849 PRJNA848679 SRS15822157 GSM6746056 GSM6746056 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333092 GSM6746057_r1 SRP379849 PRJNA848679 SRS15822158 GSM6746057 GSM6746057 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333093 GSM6746058_r1 SRP379849 PRJNA848679 SRS15822159 GSM6746058 GSM6746058 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333094 GSM6746059_r1 SRP379849 PRJNA848679 SRS15822160 GSM6746059 GSM6746059 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333095 GSM6746060_r1 SRP379849 PRJNA848679 SRS15822161 GSM6746060 GSM6746060 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500 SRX18333096 GSM6746061_r1 SRP379849 PRJNA848679 SRS15822162 GSM6746061 GSM6746061 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA from whole blood samples was isolated using a PAX gene Blood RNA kit (PreAnalytix) according to the manufacturer's instructions. The globin RNA was removed from total RNA using a GLOBINclear-Human Kit (Thermo Fisher SCIENTIFIC). For RNA sequencing, 500 ng total RNA were rRNA-depleted using the NEBNext rRNA Depletion Kit (New England Biolabs) according to the manufacturer's instructions. Library preparation was performed using an NEBNext Ultra Directional RNA Library Prep Kit (New England Biolabs). NextSeq 500