SRP409391 PRJNA904654 GSE218610 Dynamics of m6A RNA methylome during leukemogenesis reveals a role of PRMT6-MFSD2A signaling axis in maintaining AML stem cells.[RIP-seq] We delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development, and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic acid level. Overall design: m6A readers (IGF2BP2, YTHDF2, YTHDC1) RIP-seq of primary murine LICs GSE218610 pubmed 36574771 parent_bioproject PRJNA904647