SRX18368299 GSM6754655 SRP409534 SRS15854731 GSM6754655 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754655 GSM6754655 GEO Accession GSM6754655 SRX18368300 GSM6754656 SRP409534 SRS15854732 GSM6754656 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754656 GSM6754656 GEO Accession GSM6754656 SRX18368301 GSM6754657 SRP409534 SRS15854733 GSM6754657 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754657 GSM6754657 GEO Accession GSM6754657 SRX18368302 GSM6754658 SRP409534 SRS15854734 GSM6754658 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754658 GSM6754658 GEO Accession GSM6754658 SRX18368303 GSM6754659 SRP409534 SRS15854735 GSM6754659 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754659 GSM6754659 GEO Accession GSM6754659 SRX18368304 GSM6754660 SRP409534 SRS15854736 GSM6754660 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754660 GSM6754660 GEO Accession GSM6754660 SRX18368305 GSM6754661 SRP409534 SRS15854737 GSM6754661 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754661 GSM6754661 GEO Accession GSM6754661 SRX18368306 GSM6754662 SRP409534 SRS15854738 GSM6754662 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754662 GSM6754662 GEO Accession GSM6754662 SRX18368307 GSM6754663 SRP409534 SRS15854739 GSM6754663 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754663 GSM6754663 GEO Accession GSM6754663 SRX18368308 GSM6754664 SRP409534 SRS15854740 GSM6754664 Hi-C GENOMIC other We prepared Hi-C libraries using the Arima Genomics Hi-C kit (Arima Genomics, A510008) according to the manufacturer's protocol. Briefly, we enzymatically digested genomic DNA within nuclei of crosslinked cell pellets, and created biotinylated ligation junctions between the digested ends at proximity. Then we extracted DNAs and sheared to an average size of ~400 bp using a Covaris S220 sonicator at 140 W peak incident power, 10 % duty factor, and 200 cycles per burst for 55 seconds. We further size selected the sheared DNA to 200-600 bp using AgenCourt Ampure XP beads (Beckman Coulter, A63881) according to manufacturer's protocols. Biotin-tagged ligation junctions via pulldown using streptavidin breads from the Arima Hi-C kit (Arima Genomics, A510008) according to manufacturer's protocol. Streptavidin beads containing Hi-C libraries were stored at -20 °C for no more than 3 days before Illumina sequencing library preparation was performed. Hi-C libraries were prepped for sequencing by first washing adaptor-ligated Hi-C libraries on streptavidin beads twice in 150 uL of wash buffer at 55 °C and once in 100 ml of elution buffer at room temperature using Hi-C kit (Arima Genomics, A510008). DNA was eluted from streptavidin beads by boiling at 98 °C for 10 min in 15 uL elution buffer. Subsequently the libraries were amplified using NEBNext Ultra II DNA Library Prep Kit for Illumina (NEB, E7645S) with 8 PCR cycles according to the manufacturer's protocol. NextSeq 500 gds 306754664 GSM6754664 GEO Accession GSM6754664