SRX18367386 GSM6754361_r1 SRP409522 PRJNA904781 SRS15853819 GSM6754361 GSM6754361 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367387 GSM6754362_r1 SRP409522 PRJNA904781 SRS15853820 GSM6754362 GSM6754362 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367388 GSM6754363_r1 SRP409522 PRJNA904781 SRS15853821 GSM6754363 GSM6754363 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367389 GSM6754364_r1 SRP409522 PRJNA904781 SRS15853822 GSM6754364 GSM6754364 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367390 GSM6754365_r1 SRP409522 PRJNA904781 SRS15853823 GSM6754365 GSM6754365 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367391 GSM6754366_r1 SRP409522 PRJNA904781 SRS15853824 GSM6754366 GSM6754366 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367392 GSM6754367_r1 SRP409522 PRJNA904781 SRS15853825 GSM6754367 GSM6754367 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367393 GSM6754368_r1 SRP409522 PRJNA904781 SRS15853826 GSM6754368 GSM6754368 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367394 GSM6754369_r1 SRP409522 PRJNA904781 SRS15853827 GSM6754369 GSM6754369 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367395 GSM6754370_r1 SRP409522 PRJNA904781 SRS15853828 GSM6754370 GSM6754370 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367396 GSM6754371_r1 SRP409522 PRJNA904781 SRS15853829 GSM6754371 GSM6754371 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000 SRX18367397 GSM6754372_r1 SRP409522 PRJNA904781 SRS15853830 GSM6754372 GSM6754372 RNA-Seq TRANSCRIPTOMIC cDNA Blood samples were taken in Tempus tubes (Applied Biosystems, Thermofisher, UK) and stored at -80 °C, The TempusTM Spin RNA Isolation Reagent Kit was used to extract the total RNA from peripheral blood (Applied Biosystems, Thermofisher, UK) according to the manufacturer´s instructions. Sequencing was carried out at the CNAG (Centro Nacional de Análisis Genómico, Spain; https://www.cnag.crg.eu/). The RNA-Seq library was prepared with KAPA Stranded mRNA-Seq Illumina Platforms Kit (Roche) following the manufacturer´s recommendations using Illumina platform compatible adaptors with unique dual indexes and unique molecular identifiers (Integrated DNA Technologies). The final library was validated on an Agilent 2100 Bioanalyzer with the DNA 7500 assay. The libraries were sequenced on NovaSeq 6000 (Illumina) with a read length of 2x151bp following the manufacturer's protocol for dual indexing. Illumina NovaSeq 6000