SRX18374054 C1 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th17 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860461 bacteria-C1 C1 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374055 C2 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th18 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860462 bacteria-C2 C2 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374056 C11 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th27 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860463 bacteria-C11 C11 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374057 C12 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th28 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860464 bacteria-C12 C12 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374058 C13 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th29 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860465 bacteria-C13 C13 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374059 N1 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th30 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860466 bacteria-n1 N1 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374060 N2 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th31 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860467 bacteria-n2 N2 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374061 N3 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th32 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860468 bacteria-n3 N3 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374062 N4 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th33 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860469 bacteria-n4 N4 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374063 N5 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th34 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860470 bacteria-n5 N5 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374064 N6 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th35 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860471 bacteria-n6 N6 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374065 N7 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th36 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860472 bacteria-n7 N7 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374066 C3 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th19 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860473 bacteria-C3 C3 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374067 N8 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th37 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860474 bacteria-n8 N8 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374068 N9 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th38 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860475 bacteria-n9 N9 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374069 N10 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th39 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860476 bacteria-n10 N10 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374070 N11 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th40 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860477 bacteria-n11 N11 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374071 N12 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th41 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860478 bacteria-n12 N12 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374072 N13 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th42 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860479 bacteria-n13 N13 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374073 C4 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th20 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860480 bacteria-C4 C4 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374074 C5 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th21 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860481 bacteria-C5 C5 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374075 C6 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th22 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860482 bacteria-C6 C6 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374076 C7 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th23 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860483 bacteria-C7 C7 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374077 C8 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th24 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860484 bacteria-C8 C8 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374078 C9 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th25 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860485 bacteria-C9 C9 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374079 C10 SRP409631 bp0 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th26 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860486 bacteria-C10 C10 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500