SRX18374512 C1 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th17 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860915 humanC1 C1 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374513 c SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th18 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860916 humanC2 c RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374514 C3 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th19 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860917 humanC3 C3 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374515 C4 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th20 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860918 humanC4 C4 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374516 C5 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th21 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860919 humanC5 C5 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374517 T1 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th30 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860920 humanT1 T1 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374518 T2 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th31 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860921 humanT2 T2 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374519 T3 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th32 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860922 humanT3 T3 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374520 T4 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th33 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860923 humanT4 T4 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500 SRX18374521 T5 SRP409631 PRJNA905077 epsis leads to intestinal mucosal injury, bacterial translocation, and further aggravation of intestinal and remote organ injury. And intestinal injury significantly can also contribute to critical illness, sepsis and multiorgan failure. We collected fecal samples from the sepsis and the healthy . Through intestinal flora 16sRNA sequencing , intestinal metabonomic analysis and machine learning, the result shows that Intestinal flora and metabolites of intestinal flora can not only reflect the severity of sepsis, but also have good diagnostic value for sepsis. Through transcriptome sequencing and signaling analysis of of mononuclear cells in peripheral blood (PBMC)of patients with sepsis, we found that Th17 cells had significant differences in sepsis. Through the in vivo experiments, we find that L-valine, a metabolite of bacterial flora, can protect sepsis-induced intestinal injury, inhibit inflammatory response, and inhibit the expression level of Th34 cells, which provide a new strategy for the treatment of intestinal injury induced by sepsis. SRS15860924 humanT5 T5 RNA-Seq TRANSCRIPTOMIC PCR BGISEQ-500