SRS15879575 SAMN31888478 646099 human metagenome Cutaneous granulomatosis is a kind of inflammatory reaction caused by various triggers including infections, foreign bodies, malignancies, chemicals, and so on. They can be divided into non-infectious and infectious granulomas due to different pathogenic factors. Here we report a child who presented with multiple invasive skin plaques accompanied by ulceration. Biopsies were performed successively and found tuberculous granuloma several times around. But no pathogen was found by special staining, tissue culture, or RT-PCR detection. Diagnostic quadrupled anti-mycobacterium therapy was also ineffective. Then NGS made a crucial discovery, rubella virus was founded and sequenced. bioproject 905930 PRJNA905930 host Homo sapiens isolation_source changsha collection_date 2022-06-06 geo_loc_name China:changsha lat_lon 27.51 N 111.53 E BioSampleModel Metagenome or environmental