SRP410445 PRJNA906521 GSE218987 CRISPR-based epigenome editing screens identify transcriptional and epigenetic regulators of human CD8 T cell function [ATAC-seq] Human CD8+ T cells were transduced with lentivirus encoding for HER2-CAR-2A-GFP or HER2-CAR-2A-BATF3. T cells were either only stimulated once after thawing (acute stimulation) or repeatedly stimulated with HER2+ SKBR3 cells at a 1:2 effector to target (E:T) ratio every 3 days (chronic stimulation). Overall design: Comparative chromatin accessibility analysis of ATAC-seq data of acutely (n = 3) and chronically (n = 2) stimulated CD8+ T cells with or without BATF3 overexpression. GSE218987 pubmed 37205457 pubmed 37945901 parent_bioproject PRJNA906514