SRX18480467 GSM6783838_r1 SRP411180 PRJNA908102 SRS15953843 GSM6783838 GSM6783838 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480468 GSM6783839_r1 SRP411180 PRJNA908102 SRS15953844 GSM6783839 GSM6783839 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480469 GSM6783840_r1 SRP411180 PRJNA908102 SRS15953845 GSM6783840 GSM6783840 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480470 GSM6783841_r1 SRP411180 PRJNA908102 SRS15953846 GSM6783841 GSM6783841 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480471 GSM6783842_r1 SRP411180 PRJNA908102 SRS15953847 GSM6783842 GSM6783842 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480472 GSM6783843_r1 SRP411180 PRJNA908102 SRS15953848 GSM6783843 GSM6783843 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480473 GSM6783844_r1 SRP411180 PRJNA908102 SRS15953849 GSM6783844 GSM6783844 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480474 GSM6783845_r1 SRP411180 PRJNA908102 SRS15953850 GSM6783845 GSM6783845 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480475 GSM6783846_r1 SRP411180 PRJNA908102 SRS15953851 GSM6783846 GSM6783846 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten SRX18480476 GSM6783847_r1 SRP411180 PRJNA908102 SRS15953852 GSM6783847 GSM6783847 ATAC-seq GENOMIC other Microglial nuclei were first extracted with lysis buffer (0.32 M sucrose, 5 mM CaCl2, 3 mM MgAce2, 0.1 mM EDTA, 10 mM Tris-HCl, pH 8, 0.1% NP-40). Then ATAC-seq library was constructed using the reagents in TruePrep DNA Library Prep Kit V2 for Illumina (Vazyme, TD501-02). The experimental procedure was as follows: nuclei were treated with Tn5 at 37°C for 30 minutes. DNA was then purified with the MinElute Gel Extraction Kit (Qiagen, 28604) and eluted in 27ul EB buffer. 24ul of DNA samples, 10ul of 5XTAB, 5ul of PPM, 1ul of TAE, and selected aptamers (5ul of N5XX and 5ul of N7XX) (Vazyme, TD202) were mixed, followed by PCR amplification. Library DNA was purified and size-selected with SPRIselect beads (Beckman, B23318). Library quality was checked on a Qubit and Agilent 4200 Tapestation. Library was sent to Novogene in China for paired-end sequencing on Illumina XTen (2 × 150bp read length). HiSeq X Ten