SRX18541113 ancestor_BTC SRP412045 bp0 Ancestral clone used for batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006067 ancestor_BTC ancestor_BTC WGS GENOMIC RANDOM NextSeq 550 SRX18541114 caffeine_AH SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006066 caffeine_AH caffeine_AH WGS GENOMIC RANDOM NextSeq 550 SRX18541115 caffeine_JT SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006068 caffeine_JT caffeine_JT WGS GENOMIC RANDOM NextSeq 550 SRX18541116 caffeine_KS SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006069 caffeine_KS caffeine_KS WGS GENOMIC RANDOM NextSeq 550 SRX18541117 caffeine_KW_1 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006070 caffeine_KW_1 caffeine_KW_1 WGS GENOMIC RANDOM NextSeq 550 SRX18541118 caffeine_KW_2 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006071 caffeine_KW_2 caffeine_KW_2 WGS GENOMIC RANDOM NextSeq 550 SRX18541119 caffeine_MK SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006072 caffeine_MK caffeine_MK WGS GENOMIC RANDOM NextSeq 550 SRX18541120 caffeine_ML_1 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006073 caffeine_ML_1 caffeine_ML_1 WGS GENOMIC RANDOM NextSeq 550 SRX18541121 caffeine_ML_2 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006074 caffeine_ML_2 caffeine_ML_2 WGS GENOMIC RANDOM NextSeq 550 SRX18541122 caffeine_MLS SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006075 caffeine_MLS caffeine_MLS WGS GENOMIC RANDOM NextSeq 550 SRX18541123 caffeine_PA SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006077 caffeine_PA caffeine_PA WGS GENOMIC RANDOM NextSeq 550 SRX18541124 caffeine_SC SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006076 caffeine_SC caffeine_SC WGS GENOMIC RANDOM NextSeq 550 SRX18541125 caffeine_CZ SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006079 caffeine_CZ caffeine_CZ WGS GENOMIC RANDOM NextSeq 550 SRX18541126 caffeine_SS SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006078 caffeine_SS caffeine_SS WGS GENOMIC RANDOM NextSeq 550 SRX18541127 caffeine_SSL_1 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006081 caffeine_SSL_1 caffeine_SSL_1 WGS GENOMIC RANDOM NextSeq 550 SRX18541128 caffeine_SSL_2 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006080 caffeine_SSL_2 caffeine_SSL_2 WGS GENOMIC RANDOM NextSeq 550 SRX18541129 caffeine_ST SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006082 caffeine_ST caffeine_ST WGS GENOMIC RANDOM NextSeq 550 SRX18541130 caffeine_SY SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006083 caffeine_SY caffeine_SY WGS GENOMIC RANDOM NextSeq 550 SRX18541131 caffeine_TC SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006084 caffeine_TC caffeine_TC WGS GENOMIC RANDOM NextSeq 550 SRX18541132 caffeine_XM SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006085 caffeine_XM caffeine_XM WGS GENOMIC RANDOM NextSeq 550 SRX18541133 caffeine_GT SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006086 caffeine_GT caffeine_GT WGS GENOMIC RANDOM NextSeq 550 SRX18541134 caffeine_HG SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006087 caffeine_HG caffeine_HG WGS GENOMIC RANDOM NextSeq 550 SRX18541135 caffeine_ID SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006088 caffeine_ID caffeine_ID WGS GENOMIC RANDOM NextSeq 550 SRX18541136 caffeine_IM SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006089 caffeine_IM caffeine_IM WGS GENOMIC RANDOM NextSeq 550 SRX18541137 caffeine_JC_1 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006090 caffeine_JC_1 caffeine_JC_1 WGS GENOMIC RANDOM NextSeq 550 SRX18541138 caffeine_JC_2 SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006091 caffeine_JC_2 caffeine_JC_2 WGS GENOMIC RANDOM NextSeq 550 SRX18541139 caffeine_JP SRP412045 bp0 Caffeine-resistant clones were isolated from batch culture experimental evolution. Clone DNA was extracted by Hoffman-Winston method. WGS libraries were prepared by a tagmentation-based protocol. Libraries were sequenced on an Illumina NextSeq 550. SRS16006092 caffeine_JP caffeine_JP WGS GENOMIC RANDOM NextSeq 550