SRP412507 PRJNA911205 Psychosocial adversity experienced in utero and early life is associated with variation in gut microbiota Social disadvantage (SD) and psychological stressors (PS) trap some populations in poverty, resulting in health inequities. How these two factors become biologically embedded and the pathways leading to adverse health outcomes is unclear, especially in infants exposed to psychosocial adversity in utero and during early life. Variation in gut microbiome structure and functions offers a possible causative pathway. The whole metagenome shotgun datasets and 16S microbiome datasets here are used to interrogate the gut microbiome of mother-child dyads and compare high-SD/high-PS dyads to pairs with low-SD/Low-PS, and demonstrate that the GM of high-SD and high-PS mothers may already be compromised, resulting in the lowest observed inter-individual similarity in that group.