SRP413120 PRJNA912244 GSE221004 Effect of smooth muscle specific PRDM6 depletion on Aorta and Ductus Arterious (DA) development To investigate the function of PRDM6 in smooth muscle cells during outflow tract development, we have isolated the ascending aorta and the ductus arteriosus (DA) separatly from the E18.5 Wnt1Cre;PRDM6f/f mouse (PRDM6 KO) and PRDM6f/f mouse (Control) and compared the gene expression profile of the four groups of samples Overall design: There are four groups of samples in our experiment (Control Aorta; PRDM6 KO Aorta; Control DA; PRDM6 KO DA), and we focused on comparing Control DA v.s PRDM6 KO DA GSE221004 pubmed 36749647