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    <TITLE>Tumor PBMC sample from Peripheral blood of a human female participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
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    <TITLE>Non-tumor PBMC sample from Peripheral blood of a human participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>9606</TAXON_ID>
      <SCIENTIFIC_NAME>Homo sapiens</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_accession</TAG>
        <VALUE>phs002705</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitter handle</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study name</TAG>
        <VALUE>Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study design</TAG>
        <VALUE>Collection</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository sample id</TAG>
        <VALUE>HD1</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>submitted sample id</TAG>
        <VALUE>HD1</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>submitted subject id</TAG>
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      <SAMPLE_ATTRIBUTE>
        <TAG>gap_sample_id</TAG>
        <VALUE>4862968</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_subject_id</TAG>
        <VALUE>3862250</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>body site</TAG>
        <VALUE>Peripheral blood</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>histological type</TAG>
        <VALUE>Healthy donor</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>analyte type</TAG>
        <VALUE>PBMC</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>is tumor</TAG>
        <VALUE>No</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_code</TAG>
        <VALUE>1</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_short_name</TAG>
        <VALUE>HMB</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="HD2" accession="SRS16155401">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS16155401</PRIMARY_ID>
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      <EXTERNAL_ID namespace="dbGaP" label="Sample name">2705-HD2</EXTERNAL_ID>
      <EXTERNAL_ID namespace="phs002705" label="submitted sample id">HD2</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>Non-tumor PBMC sample from Peripheral blood of a human participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>9606</TAXON_ID>
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    </SAMPLE_NAME>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>phs002705</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>submitter handle</TAG>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>study name</TAG>
        <VALUE>Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
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        <VALUE>Collection</VALUE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>gap_subject_id</TAG>
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      <SAMPLE_ATTRIBUTE>
        <TAG>body site</TAG>
        <VALUE>Peripheral blood</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>histological type</TAG>
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      <SAMPLE_ATTRIBUTE>
        <TAG>analyte type</TAG>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>1</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_short_name</TAG>
        <VALUE>HMB</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="MBL-CLL1_T1" accession="SRS16155402">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS16155402</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN25943249</EXTERNAL_ID>
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    <TITLE>Tumor PBMC sample from Peripheral blood of a human male participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>study name</TAG>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>MBL-CLL1_T1</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>submitted sample id</TAG>
        <VALUE>MBL-CLL1_T1</VALUE>
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      <SAMPLE_ATTRIBUTE>
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        <TAG>gap_sample_id</TAG>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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        <VALUE>PBMC</VALUE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="MBL-CLL1_T2" accession="SRS16155403">
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      <PRIMARY_ID>SRS16155403</PRIMARY_ID>
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    <TITLE>Tumor PBMC sample from Peripheral blood of a human male participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <SAMPLE_ATTRIBUTE>
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      <PRIMARY_ID>SRS16155404</PRIMARY_ID>
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    <SAMPLE_NAME>
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    <TITLE>Tumor PBMC sample from Peripheral blood of a human female participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
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    <SAMPLE_NAME>
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    <SAMPLE_NAME>
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      <SAMPLE_ATTRIBUTE>
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    <SAMPLE_NAME>
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    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_accession</TAG>
        <VALUE>phs002705</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitter handle</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study name</TAG>
        <VALUE>Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study design</TAG>
        <VALUE>Collection</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository sample id</TAG>
        <VALUE>MBL3_T1</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitted sample id</TAG>
        <VALUE>MBL3_T1</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitted subject id</TAG>
        <VALUE>MBL3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_sample_id</TAG>
        <VALUE>4862982</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_subject_id</TAG>
        <VALUE>3862258</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>sex</TAG>
        <VALUE>male</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>body site</TAG>
        <VALUE>Peripheral blood</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>histological type</TAG>
        <VALUE>Monoclonal B lymphocytosis</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>analyte type</TAG>
        <VALUE>PBMC</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>is tumor</TAG>
        <VALUE>Yes</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_code</TAG>
        <VALUE>1</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_short_name</TAG>
        <VALUE>HMB</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="MBL3_T2" accession="SRS16155415">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS16155415</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN25943237</EXTERNAL_ID>
      <EXTERNAL_ID namespace="dbGaP" label="Sample name">2705-MBL3_T2</EXTERNAL_ID>
      <EXTERNAL_ID namespace="phs002705" label="submitted sample id">MBL3_T2</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>Tumor PBMC sample from Peripheral blood of a human male participant in the dbGaP study "Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib"</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>9606</TAXON_ID>
      <SCIENTIFIC_NAME>Homo sapiens</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_accession</TAG>
        <VALUE>phs002705</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitter handle</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository</TAG>
        <VALUE>NCI_CLL_Reversal_Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study name</TAG>
        <VALUE>Single Cell Analysis Reveals Immune Dysfunction from the Earliest Stages of CLL that can be Reversed by Ibrutinib</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>study design</TAG>
        <VALUE>Collection</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>biospecimen repository sample id</TAG>
        <VALUE>MBL3_T2</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitted sample id</TAG>
        <VALUE>MBL3_T2</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>submitted subject id</TAG>
        <VALUE>MBL3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_sample_id</TAG>
        <VALUE>4862983</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_subject_id</TAG>
        <VALUE>3862258</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>sex</TAG>
        <VALUE>male</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>body site</TAG>
        <VALUE>Peripheral blood</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>histological type</TAG>
        <VALUE>Monoclonal B lymphocytosis</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>analyte type</TAG>
        <VALUE>PBMC</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>is tumor</TAG>
        <VALUE>Yes</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_code</TAG>
        <VALUE>1</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>gap_consent_short_name</TAG>
        <VALUE>HMB</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
</SAMPLE_SET>
