SRX19877304 raw.split.Control1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-3-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232473 raw.split.Control1 raw.split.Control1 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877305 raw.split.Control2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-4-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232474 raw.split.Control2 raw.split.Control2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877306 abx_con2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-13-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232475 abx_con2 abx_con2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877307 abx_con3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-14-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232476 abx_con3 abx_con3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877308 abx_con4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-15-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232477 abx_con4 abx_con4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877309 AbX_CRS1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-16-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232478 AbX_CRS1 AbX_CRS1 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877310 AbX_CRS2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-17-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232479 AbX_CRS2 AbX_CRS2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877311 AbX_CRS3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-18-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232480 AbX_CRS3 AbX_CRS3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877312 AbX_CRS4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-19-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232481 AbX_CRS4 AbX_CRS4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877313 Con1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-20-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232482 Con1 Con1 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877314 Con2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-21-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232483 Con2 Con2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877315 Con3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-22-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232484 Con3 Con3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877316 raw.split.Control3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-5-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232485 raw.split.Control3 raw.split.Control3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877317 Con4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-23-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232486 Con4 Con4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877318 CRS1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-24-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232487 CRS1 CRS1 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877319 CRS2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-25-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232488 CRS2 CRS2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877320 CRS3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-26-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232489 CRS3 CRS3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877321 CRS4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-27-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232490 CRS4 CRS4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877322 raw.split.Control4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-6-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232491 raw.split.Control4 raw.split.Control4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877323 raw.split.Stress1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-7-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232492 raw.split.Stress1 raw.split.Stress1 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877324 raw.split.Stress2 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-8-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232493 raw.split.Stress2 raw.split.Stress2 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877325 raw.split.Stress3 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-9-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232494 raw.split.Stress3 raw.split.Stress3 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877326 raw.split.Stress4 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-10-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232495 raw.split.Stress4 raw.split.Stress4 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877327 raw.split.Stress5 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-11-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232496 raw.split.Stress5 raw.split.Stress5 AMPLICON GENOMIC PCR Illumina MiSeq SRX19877328 abx_con1 SRP430999 bp0 The brain and gut are intricately connected in response to various stressful stimuli. Here we describe a brain-to-gut pathway in mice that instructs intestinal stem cells (ISCs) lineage commitment via bacterial metabolic signals. Psychological stress signals from the brain trigger a sympathetic pathway to enrich gut commensal Lactobacillus, which contributes to a transferrable loss of intestinal secretory cell subtypes. Indole-12-acetate (IAA) production by Lactobacillus murinus disrupts mitochondrial bioenergetics of ISCs and blocks secretory lineage commitment. In patients with mental stress, we observe similar enrichment of IAA and Lactobacillus species associated with gut dysfunction. These findings uncover a stress-responsive brain-gut signalling mechanism that skews ISCs fate decision and could be targeted for stress-driven gut-brain comorbidities. SRS17232497 abx_con1 abx_con1 AMPLICON GENOMIC PCR Illumina MiSeq