SRX22443472 GSM7887113_r1 SRP470947 PRJNA1037107 SRS19461191 GSM7887113 GSM7887113 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443473 GSM7887114_r1 SRP470947 PRJNA1037107 SRS19461190 GSM7887114 GSM7887114 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443474 GSM7887115_r1 SRP470947 PRJNA1037107 SRS19461193 GSM7887115 GSM7887115 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443475 GSM7887116_r1 SRP470947 PRJNA1037107 SRS19461192 GSM7887116 GSM7887116 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443476 GSM7887117_r1 SRP470947 PRJNA1037107 SRS19461195 GSM7887117 GSM7887117 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443477 GSM7887118_r1 SRP470947 PRJNA1037107 SRS19461194 GSM7887118 GSM7887118 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443478 GSM7887119_r1 SRP470947 PRJNA1037107 SRS19461196 GSM7887119 GSM7887119 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443479 GSM7887120_r1 SRP470947 PRJNA1037107 SRS19461197 GSM7887120 GSM7887120 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443480 GSM7887121_r1 SRP470947 PRJNA1037107 SRS19461198 GSM7887121 GSM7887121 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443481 GSM7887122_r1 SRP470947 PRJNA1037107 SRS19461199 GSM7887122 GSM7887122 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443482 GSM7887123_r1 SRP470947 PRJNA1037107 SRS19461200 GSM7887123 GSM7887123 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443483 GSM7887124_r1 SRP470947 PRJNA1037107 SRS19461201 GSM7887124 GSM7887124 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443484 GSM7887125_r1 SRP470947 PRJNA1037107 SRS19461202 GSM7887125 GSM7887125 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443485 GSM7887126_r1 SRP470947 PRJNA1037107 SRS19461203 GSM7887126 GSM7887126 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443486 GSM7887127_r1 SRP470947 PRJNA1037107 SRS19461205 GSM7887127 GSM7887127 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443487 GSM7887128_r1 SRP470947 PRJNA1037107 SRS19461204 GSM7887128 GSM7887128 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443488 GSM7887129_r1 SRP470947 PRJNA1037107 SRS19461206 GSM7887129 GSM7887129 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000 SRX22443489 GSM7887130_r1 SRP470947 PRJNA1037107 SRS19461207 GSM7887130 GSM7887130 Bisulfite-Seq GENOMIC Reduced Representation DNA was extracted from retinal ganglion cells using the Quick-DNA Microprep Plus Kit (Zymo Research D4074) following the manufacture's manual. RRBS library preparation and sequencing were done by Zymo Research. Briefly, 10 ng genomic DNA was digested with 30 units of MspI. Fragments were ligated to pre-annealed adapters containing 5'-methyl-cytosine instead of cytosine according to Illumina's specified guidelines. Adaptor-ligated fragments ≥ 50 bp in size were recovered using the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). The fragments were then bisulfite-treated using the EZ DNA Methylation-Lightning Kit (Zymo Research D5030). Preparative-scale PCR was performed, and the product was purified with the DNA Clean & Concentrator-5 Kit (Zymo Research D4003). Illumina NovaSeq 6000