SRX22486847 GSM7891015_r1 SRP471335 PRJNA1039267 SRS19500192 GSM7891015 GSM7891015 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486848 GSM7891016_r1 SRP471335 PRJNA1039267 SRS19500193 GSM7891016 GSM7891016 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486849 GSM7891017_r1 SRP471335 PRJNA1039267 SRS19500194 GSM7891017 GSM7891017 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486850 GSM7891018_r1 SRP471335 PRJNA1039267 SRS19500195 GSM7891018 GSM7891018 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486851 GSM7891019_r1 SRP471335 PRJNA1039267 SRS19500196 GSM7891019 GSM7891019 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486852 GSM7891020_r1 SRP471335 PRJNA1039267 SRS19500197 GSM7891020 GSM7891020 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486853 GSM7891021_r1 SRP471335 PRJNA1039267 SRS19500198 GSM7891021 GSM7891021 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486854 GSM7891022_r1 SRP471335 PRJNA1039267 SRS19500199 GSM7891022 GSM7891022 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486855 GSM7891023_r1 SRP471335 PRJNA1039267 SRS19500200 GSM7891023 GSM7891023 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486856 GSM7891024_r1 SRP471335 PRJNA1039267 SRS19500201 GSM7891024 GSM7891024 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486857 GSM7891025_r1 SRP471335 PRJNA1039267 SRS19500202 GSM7891025 GSM7891025 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486858 GSM7891026_r1 SRP471335 PRJNA1039267 SRS19500204 GSM7891026 GSM7891026 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486859 GSM7891027_r1 SRP471335 PRJNA1039267 SRS19500203 GSM7891027 GSM7891027 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486860 GSM7891028_r1 SRP471335 PRJNA1039267 SRS19500205 GSM7891028 GSM7891028 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486861 GSM7891029_r1 SRP471335 PRJNA1039267 SRS19500206 GSM7891029 GSM7891029 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486862 GSM7891030_r1 SRP471335 PRJNA1039267 SRS19500207 GSM7891030 GSM7891030 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486863 GSM7891031_r1 SRP471335 PRJNA1039267 SRS19500208 GSM7891031 GSM7891031 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486864 GSM7891032_r1 SRP471335 PRJNA1039267 SRS19500209 GSM7891032 GSM7891032 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486865 GSM7891033_r1 SRP471335 PRJNA1039267 SRS19500211 GSM7891033 GSM7891033 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486866 GSM7891034_r1 SRP471335 PRJNA1039267 SRS19500210 GSM7891034 GSM7891034 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486867 GSM7891035_r1 SRP471335 PRJNA1039267 SRS19500212 GSM7891035 GSM7891035 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486868 GSM7891036_r1 SRP471335 PRJNA1039267 SRS19500213 GSM7891036 GSM7891036 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486869 GSM7891037_r1 SRP471335 PRJNA1039267 SRS19500214 GSM7891037 GSM7891037 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486870 GSM7891038_r1 SRP471335 PRJNA1039267 SRS19500216 GSM7891038 GSM7891038 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486871 GSM7891039_r1 SRP471335 PRJNA1039267 SRS19500215 GSM7891039 GSM7891039 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486872 GSM7891040_r1 SRP471335 PRJNA1039267 SRS19500217 GSM7891040 GSM7891040 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486873 GSM7891041_r1 SRP471335 PRJNA1039267 SRS19500218 GSM7891041 GSM7891041 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486874 GSM7891042_r1 SRP471335 PRJNA1039267 SRS19500219 GSM7891042 GSM7891042 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486875 GSM7891043_r1 SRP471335 PRJNA1039267 SRS19500220 GSM7891043 GSM7891043 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486876 GSM7891044_r1 SRP471335 PRJNA1039267 SRS19500221 GSM7891044 GSM7891044 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486877 GSM7891045_r1 SRP471335 PRJNA1039267 SRS19500222 GSM7891045 GSM7891045 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486878 GSM7891046_r1 SRP471335 PRJNA1039267 SRS19500223 GSM7891046 GSM7891046 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486879 GSM7891047_r1 SRP471335 PRJNA1039267 SRS19500224 GSM7891047 GSM7891047 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486880 GSM7891048_r1 SRP471335 PRJNA1039267 SRS19500225 GSM7891048 GSM7891048 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486881 GSM7891049_r1 SRP471335 PRJNA1039267 SRS19500226 GSM7891049 GSM7891049 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486882 GSM7891050_r1 SRP471335 PRJNA1039267 SRS19500227 GSM7891050 GSM7891050 RNA-Seq TRANSCRIPTOMIC cDNA On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, RNA extraction was performed using the Invitrogen PureLink RNA Mini Kit (Thermo Fisher Scientific #12183018A), as per the manufacturer's protocol. Sequencing libraries were prepared using the poly(A) selection method at the CRG Genomics Core Facility. Illumina HiSeq 2500 SRX22486883 GSM7891051_r1 SRP471335 PRJNA1039267 SRS19500228 GSM7891051 GSM7891051 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486884 GSM7891052_r1 SRP471335 PRJNA1039267 SRS19500229 GSM7891052 GSM7891052 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486885 GSM7891053_r1 SRP471335 PRJNA1039267 SRS19500230 GSM7891053 GSM7891053 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486886 GSM7891054_r1 SRP471335 PRJNA1039267 SRS19500231 GSM7891054 GSM7891054 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486887 GSM7891055_r1 SRP471335 PRJNA1039267 SRS19500232 GSM7891055 GSM7891055 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486888 GSM7891056_r1 SRP471335 PRJNA1039267 SRS19500233 GSM7891056 GSM7891056 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486889 GSM7891057_r1 SRP471335 PRJNA1039267 SRS19500234 GSM7891057 GSM7891057 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486890 GSM7891058_r1 SRP471335 PRJNA1039267 SRS19500235 GSM7891058 GSM7891058 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486891 GSM7891059_r1 SRP471335 PRJNA1039267 SRS19500236 GSM7891059 GSM7891059 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486892 GSM7891060_r1 SRP471335 PRJNA1039267 SRS19500237 GSM7891060 GSM7891060 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486893 GSM7891061_r1 SRP471335 PRJNA1039267 SRS19500238 GSM7891061 GSM7891061 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486894 GSM7891062_r1 SRP471335 PRJNA1039267 SRS19500239 GSM7891062 GSM7891062 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486895 GSM7891063_r1 SRP471335 PRJNA1039267 SRS19500240 GSM7891063 GSM7891063 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486896 GSM7891064_r1 SRP471335 PRJNA1039267 SRS19500241 GSM7891064 GSM7891064 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486897 GSM7891065_r1 SRP471335 PRJNA1039267 SRS19500242 GSM7891065 GSM7891065 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486898 GSM7891066_r1 SRP471335 PRJNA1039267 SRS19500243 GSM7891066 GSM7891066 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486899 GSM7891067_r1 SRP471335 PRJNA1039267 SRS19500244 GSM7891067 GSM7891067 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486900 GSM7891068_r1 SRP471335 PRJNA1039267 SRS19500245 GSM7891068 GSM7891068 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486901 GSM7891069_r1 SRP471335 PRJNA1039267 SRS19500246 GSM7891069 GSM7891069 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486902 GSM7891070_r1 SRP471335 PRJNA1039267 SRS19500247 GSM7891070 GSM7891070 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486903 GSM7891071_r1 SRP471335 PRJNA1039267 SRS19500248 GSM7891071 GSM7891071 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486904 GSM7891072_r1 SRP471335 PRJNA1039267 SRS19500249 GSM7891072 GSM7891072 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486905 GSM7891073_r1 SRP471335 PRJNA1039267 SRS19500250 GSM7891073 GSM7891073 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486906 GSM7891074_r1 SRP471335 PRJNA1039267 SRS19500251 GSM7891074 GSM7891074 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486907 GSM7891075_r1 SRP471335 PRJNA1039267 SRS19500252 GSM7891075 GSM7891075 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486908 GSM7891076_r1 SRP471335 PRJNA1039267 SRS19500253 GSM7891076 GSM7891076 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486909 GSM7891077_r1 SRP471335 PRJNA1039267 SRS19500254 GSM7891077 GSM7891077 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486910 GSM7891078_r1 SRP471335 PRJNA1039267 SRS19500255 GSM7891078 GSM7891078 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486911 GSM7891079_r1 SRP471335 PRJNA1039267 SRS19500256 GSM7891079 GSM7891079 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486912 GSM7891080_r1 SRP471335 PRJNA1039267 SRS19500257 GSM7891080 GSM7891080 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486913 GSM7891081_r1 SRP471335 PRJNA1039267 SRS19500258 GSM7891081 GSM7891081 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486914 GSM7891082_r1 SRP471335 PRJNA1039267 SRS19500259 GSM7891082 GSM7891082 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486915 GSM7891083_r1 SRP471335 PRJNA1039267 SRS19500260 GSM7891083 GSM7891083 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486916 GSM7891084_r1 SRP471335 PRJNA1039267 SRS19500261 GSM7891084 GSM7891084 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486917 GSM7891085_r1 SRP471335 PRJNA1039267 SRS19500263 GSM7891085 GSM7891085 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500 SRX22486918 GSM7891086_r1 SRP471335 PRJNA1039267 SRS19500262 GSM7891086 GSM7891086 ATAC-seq GENOMIC other On days 3, 7, 14 and 21 cells were trypsinised, centrifuged and cell pellets flash frozen using liquid nitrogen. Storage of cell pellets was at -70 oC. Once samples from all time points were collected, 50,000 MIA PaCa-2 cells for each treated condition/replicate infected was collected and treated with transposase Tn5 (Nextera Tn5 Transposase; Illumina Cat #FC-121-1030). DNA was purified using AMPure XP beads to remove large fragments (0.5 × beads; >1kb) and small fragments (1.5 × beads; < 100bp). Samples were then amplified using NEBNext high-Fidelity 2x PCR Master Mix (New England Labs #M0541) with primers containing a barcode to generate the libraries Libraries were prepared for sequencing using standard Illumina protocols Illumina HiSeq 2500