SRP475058 PRJNA1046703 The impact of primary SARS-CoV-2 infection to human anelloviruses Members of the Anelloviridae family have been infecting humans for over thousands of years and dominate the blood virome. All anelloviruses infecting an individual contribute to someones personal anellome, which is relatively stable in time. Here, we investigated the blood anellome during a primary SARS-CoV-2 infection of a cohort containing hospital health care workers from the Amsterdam UMC hospital.