SRP478165 PRJNA1052958 RNA sequencing from Pwwp3a KO mice Pwwp3a, as a reader of H3K36me2/H3K36me3, is a response factor to DNA damage and promotes cell survival. However, the physiological role of Pwwp3a in spermatogenesis and fertility remains clear. We detected changes in the transcriptome in the testis after Pwwp3a depletion.