<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE259277" accession="SRP491856">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP491856</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA1080570</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE259277</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>Effect of miR-33 supression in hepatocytes in NAFLD and NASH</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>We perform sc-RNAseq in NASH  livers from WT and miR-33-AlbCRE  conditional knock-out mice. Liver were isolated from mice after 6 months of feeding a choline deficient high fat diet to analyze the effect of miR-33 deficiency specifically in hepatocytes and the crosstalk between hepatocytes and other cell types in the liver. Overall design: Liver single cell suspension from WT and mir-33 HKO mice after 6 months of CD-HFD feeding to indunce NASH.</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE259277</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
  </STUDY>
</STUDY_SET>
