<?xml version="1.0" encoding="UTF-8"?>
<STUDY_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <STUDY center_name="GEO" alias="GSE260476" accession="SRP492344">
    <IDENTIFIERS>
      <PRIMARY_ID>SRP492344</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioProject" label="primary">PRJNA1081851</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSE260476</EXTERNAL_ID>
    </IDENTIFIERS>
    <DESCRIPTOR>
      <STUDY_TITLE>RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing</STUDY_TITLE>
      <STUDY_TYPE existing_study_type="Transcriptome Analysis"/>
      <STUDY_ABSTRACT>Transparent avascular cornea providing two third refraction to the eye. Restoration of corneal transparency and clear vision in a traumatic eye involves the action of many cytokines and signaling pathways. Out of several factors, stromal keratocytes/fibroblasts (CSFs) play a central role in corneal repair and wound healing. Post trauma, keratocytes/fibroblasts produce myofibroblasts to facilitate wound repair by synthesizing and secreting large extracellular matrix components, collagens, and alpha-smooth muscle actin stress fibers. This study aimed to perform RNASeq data analysis and pathway enrichments to gain a better understanding of gene regulation in corneal fibroblasts and myofibroblasts in corneal wound repair. Overall design: To investigate differential gene expression, pathway enrichment, and gene regulation in corneal fibroblasts and myofibroblasts in corneal wound repair</STUDY_ABSTRACT>
      <CENTER_PROJECT_NAME>GSE260476</CENTER_PROJECT_NAME>
    </DESCRIPTOR>
    <STUDY_LINKS>
      <STUDY_LINK>
        <XREF_LINK>
          <DB>pubmed</DB>
          <ID>39240550</ID>
        </XREF_LINK>
      </STUDY_LINK>
    </STUDY_LINKS>
  </STUDY>
</STUDY_SET>
