<?xml version="1.0" encoding="UTF-8"?>
<SAMPLE_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <SAMPLE alias="GSM8120853" accession="SRS20621767">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621767</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206500</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120853</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 1</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
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      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.2</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120855" accession="SRS20621768">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621768</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206498</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120855</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, AAV, 12mo, rep 1</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>AAV-8D3:PGRN</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>300000000000 vg</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.5</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120854" accession="SRS20621769">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621769</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206499</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120854</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, Saline, 12mo, rep 1</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120856" accession="SRS20621770">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621770</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206497</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120856</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 2</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.2</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120857" accession="SRS20621771">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621771</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206496</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120857</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, Saline, 12mo, rep 2</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.2</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
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    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120858" accession="SRS20621772">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621772</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206495</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120858</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, AAV, 12mo, rep 2</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
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      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>AAV-8D3:PGRN</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>300000000000 vg</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.2 months</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
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  </SAMPLE>
  <SAMPLE alias="GSM8120859" accession="SRS20621773">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621773</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206494</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120859</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 3</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
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      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>8.0</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.43 months</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
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  <SAMPLE alias="GSM8120860" accession="SRS20621774">
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      <PRIMARY_ID>SRS20621774</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206493</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120860</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, Saline, 12mo, rep 3</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
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        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.3</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.67 months</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
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  <SAMPLE alias="GSM8120862" accession="SRS20621775">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621775</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206491</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120862</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 4</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
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      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
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        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.7 months</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
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  </SAMPLE>
  <SAMPLE alias="GSM8120863" accession="SRS20621776">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621776</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206490</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120863</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, Saline, 12mo, rep 4</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
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      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>8.0</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.7 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
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  </SAMPLE>
  <SAMPLE alias="GSM8120861" accession="SRS20621777">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621777</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206492</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120861</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, AAV, 12mo, rep 3</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
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      <SAMPLE_ATTRIBUTE>
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        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
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      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>AAV-8D3:PGRN</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>300000000000 vg</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.4</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.7 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120864" accession="SRS20621778">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621778</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206489</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120864</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, AAV, 12mo, rep 4</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>AAV-8D3:PGRN</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>300000000000 vg</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.5</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.23 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120866" accession="SRS20621779">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621779</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206487</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120866</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, Saline, 12mo, rep 5</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.6</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.0 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120865" accession="SRS20621780">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621780</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206488</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120865</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 5</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.3</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.93 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120867" accession="SRS20621781">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621781</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206486</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120867</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>KO, AAV, 12mo, rep 5</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn KO</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>AAV-8D3:PGRN</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>300000000000 vg</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.6</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.0 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
  <SAMPLE alias="GSM8120868" accession="SRS20621782">
    <IDENTIFIERS>
      <PRIMARY_ID>SRS20621782</PRIMARY_ID>
      <EXTERNAL_ID namespace="BioSample">SAMN40206485</EXTERNAL_ID>
      <EXTERNAL_ID namespace="GEO">GSM8120868</EXTERNAL_ID>
    </IDENTIFIERS>
    <TITLE>WT, Saline, 12mo, rep 6</TITLE>
    <SAMPLE_NAME>
      <TAXON_ID>10090</TAXON_ID>
      <SCIENTIFIC_NAME>Mus musculus</SCIENTIFIC_NAME>
    </SAMPLE_NAME>
    <SAMPLE_LINKS>
      <SAMPLE_LINK>
        <XREF_LINK>
          <DB>bioproject</DB>
          <ID>1082327</ID>
          <LABEL>PRJNA1082327</LABEL>
        </XREF_LINK>
      </SAMPLE_LINK>
    </SAMPLE_LINKS>
    <SAMPLE_ATTRIBUTES>
      <SAMPLE_ATTRIBUTE>
        <TAG>source_name</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>tissue</TAG>
        <VALUE>cortex</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>genotype</TAG>
        <VALUE>Grn WT</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment</TAG>
        <VALUE>Saline</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>treatment dose</TAG>
        <VALUE>None</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>rin</TAG>
        <VALUE>9.5</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>age</TAG>
        <VALUE>12.93 months</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>geo_loc_name</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
      <SAMPLE_ATTRIBUTE>
        <TAG>collection_date</TAG>
        <VALUE>missing</VALUE>
      </SAMPLE_ATTRIBUTE>
    </SAMPLE_ATTRIBUTES>
  </SAMPLE>
</SAMPLE_SET>
