SRX23801310 001 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624301 WTCtrl 001 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000 SRX23801311 002 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624302 WTLPS 002 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000 SRX23801312 003 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624303 WTIAV 003 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000 SRX23801313 004 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624304 KOCtrl 004 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000 SRX23801314 005 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624305 KOLPS 005 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000 SRX23801315 006 SRP492681 bp0 Total RNA was prepared from Zfand6+/+ and Zfand6/ BMDMs, either untreated, treated with LPS or infected with IAV (PR8) for 24 h. RNA-Seq and bioinformatics was performed by the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center next-generation sequencing core as previously described (Lavorgna et al. PloS. Pathog. 2014). Illumina next-gen sequencing reads were mapped with RSEM, aligned to a mouse genome reference library and analyzed with RSEM, EBSeq, Tophat and Cufflinks. The differential expression analysis was performed with the DEseq R package and GO enrichment with the topGO R package. Gene set enrichment analysis (GSEA) was performed using GSEA (Broad Institute, broadinstitute.org/GSEA). SRS20624306 KOIAV 006 RNA-Seq TRANSCRIPTOMIC PolyA Illumina NovaSeq 6000