<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="BT325 bulk" accession="SRX848889" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX848889</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BT325 bulk</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-genome sequencing of bulk DNA from frozen glioblastoma BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>DNA is extracted from a pool of flow sorted glioblastoma nuclei and subjected to whole-genome sequencing.</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS823750">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS823750</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME>BT325</LIBRARY_NAME>
        <LIBRARY_STRATEGY>WGS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>unspecified</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>202</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>102</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa</PROGRAM>
          <VERSION>0.6.1-r112-master</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.473(1346)</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BL325_CCGD" accession="SRX851083" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX851083</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BL325_CCGD</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-genome sequencing of bulk blood DNA of BT325 patient</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS829893">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS829893</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WGS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>unspecified</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>202</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>102</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa</PROGRAM>
          <VERSION>0.6.1-r112-master</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.474(1351)</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BT325_WES_Tumor" accession="SRX857666" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX857666</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BT325_WES_Tumor</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-exome sequencing of bulk DNA from frozen glioblastoma BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS823750">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS823750</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WXS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>Hybrid Selection</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>152</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>77</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa -q5 -l 32 -k 2 -o 1</PROGRAM>
          <VERSION>0.5.9-tpx</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.464(1311)</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK Table Recalibration</PROGRAM>
          <VERSION>1.4-14-g3550ea7</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK IndelRealigner</PROGRAM>
          <VERSION>1.4-14-g3550ea7</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BL325_WES_blood" accession="SRX857684" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX857684</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BL325_WES_blood</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-exome sequencing of bulk blood DNA from patient BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS829893">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS829893</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WXS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>Hybrid Selection</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>152</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>77</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa -q 5 -l 32 -k 2 -o 1</PROGRAM>
          <VERSION>0.5.9-tpx</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK TableRecalibration</PROGRAM>
          <VERSION>1.4-14-g3550ea7</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.464(1311)</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK IndelRealigner</PROGRAM>
          <VERSION>1.4-14-g3550ea7</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BT325_single_cells_pool1" accession="SRX858332" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX858332</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BT325_single_cells_pool1</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-genome sequencing of whole-genome amplified DNA from 59 single nuclei from brain tumor patient BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>DNA was isolated from flow-sorted single nuclei, subjected to whole-genome amplification by multiple-displacement amplification, and then made into standard illumina whole-genome libraries.</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS823750">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS823750</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WGS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>unspecified</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>160</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>81</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2000</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa</PROGRAM>
          <VERSION>0.6.1-r112-master</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.474(1351)</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BT325_single_cells_pool2" accession="SRX858334" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX858334</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BT325_single_cells_pool2</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-genome sequencing of whole-genome amplified DNA from 40 single nuclei from brain tumor patient BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION>DNA was isolated from flow-sorted single nuclei, subjected to whole-genome amplification by multiple-displacement amplification, and then made into standard illumina whole-genome libraries.</DESIGN_DESCRIPTION>
      <SAMPLE_DESCRIPTOR accession="SRS823750">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS823750</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WGS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>unspecified</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>202</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>102</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa</PROGRAM>
          <VERSION>0.6.1-r112-master</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.474(1351)</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
  <EXPERIMENT alias="BT325_single_selected" accession="SRX858848" center_name="Dana-Farber Cancer Institute">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX858848</PRIMARY_ID>
      <SUBMITTER_ID namespace="Dana-Farber Cancer Institute">BT325_single_selected</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>Whole-genome sequencing of whole-genome amplified DNA from 4 single nuclei from brain tumor patient BT325</TITLE>
    <STUDY_REF accession="SRP052627">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP052627</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS823750">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS823750</PRIMARY_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_NAME/>
        <LIBRARY_STRATEGY>WGS</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>unspecified</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED NOMINAL_SDEV="0.0E0"/>
        </LIBRARY_LAYOUT>
      </LIBRARY_DESCRIPTOR>
      <SPOT_DESCRIPTOR>
        <SPOT_DECODE_SPEC>
          <SPOT_LENGTH>202</SPOT_LENGTH>
          <READ_SPEC>
            <READ_INDEX>0</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Forward</READ_TYPE>
            <BASE_COORD>1</BASE_COORD>
          </READ_SPEC>
          <READ_SPEC>
            <READ_INDEX>1</READ_INDEX>
            <READ_CLASS>Application Read</READ_CLASS>
            <READ_TYPE>Reverse</READ_TYPE>
            <BASE_COORD>102</BASE_COORD>
          </READ_SPEC>
        </SPOT_DECODE_SPEC>
      </SPOT_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina HiSeq 2500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <PROCESSING>
      <PIPELINE>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>bwa</PROGRAM>
          <VERSION>0.5.9</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK TableRecalibration</PROGRAM>
          <VERSION>1.6-5-g557a77</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>MarkDuplicates</PROGRAM>
          <VERSION>1.92(1464)</VERSION>
        </PIPE_SECTION>
        <PIPE_SECTION>
          <STEP_INDEX/>
          <PREV_STEP_INDEX/>
          <PROGRAM>GATK IndelRealigner</PROGRAM>
          <VERSION>1.6-5-g557da77</VERSION>
        </PIPE_SECTION>
      </PIPELINE>
    </PROCESSING>
  </EXPERIMENT>
</EXPERIMENT_SET>
