SRX1047413 GSM1701825 SRP059034 SRS951798 GSM1701825 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701825 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701825 gds 301701825 GEO Accession GSM1701825 SRX1047414 GSM1701826 SRP059034 SRS951797 GSM1701826 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701826 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701826 gds 301701826 GEO Accession GSM1701826 SRX1047415 GSM1701827 SRP059034 SRS951796 GSM1701827 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701827 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701827 gds 301701827 GEO Accession GSM1701827 SRX1047416 GSM1701828 SRP059034 SRS951795 GSM1701828 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701828 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701828 gds 301701828 GEO Accession GSM1701828 SRX1047417 GSM1701829 SRP059034 SRS951794 GSM1701829 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701829 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701829 gds 301701829 GEO Accession GSM1701829 SRX1047418 GSM1701830 SRP059034 SRS951793 GSM1701830 ChIP-Seq GENOMIC ChIP Lysates were clarified from sonicated nuclei and SOX2-DNA complexes and POI II-DNA complexes were immunoprecipitated with SOX2 antibody (R&D AF2018) or POI II antibody (Covance MMS-126R). Protein A and G Magenetic Dynabeads were used to capture antibody bound protein-DNA complexes. ChIP-seq libraries preparation: The ChIP-enriched DNA samples were treated with end-repair of the DNA, adding ‘‘A” bases to the DNA, ligating sequencing adapters to DNA fragments, amplifying adapter-modified DNA by PCR and gel purification for ChIPseq using NEBNext Ultra DNA Library Prep Kit for Illumina. Purified libraries were sequenced on Illumina HiSeq2500 platforms. Illumina HiSeq 2500 GEO Sample GSM1701830 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM1701830 gds 301701830 GEO Accession GSM1701830