SRX1161826 Whole exome sequencing of ovarian dysgenesis female 17592 SRP062710 Genomic DNA was extracted from peripheral blood using a homemade DNA extraction kit based on the "salting-out" method, and dissolved in low TE (1mM Tris-Hcl pH=8, 0.1mM EDTA). DNA quality and quantity was assessed using a Nanodrop Spectrophotometer and agarose gel electrophoresis. Libraries prepared from genomic DNA were hybridized to biotinylated cRNA oligonucleotide baits from the SureSelect Human All Exon Kit (Agilent Technologies, Santa Clara, California). Each exome-enriched library was sequenced with 50bp paired-end reads on two lanes of an ABI SOLiD-3 plus analyzer. SRS1042714 WXS GENOMIC Hybrid Selection 85 0 Application Read Forward 1 1 Application Read Reverse 51 AB SOLiD 3 Plus System Burrows-Wheeler Aligner (BWA) February 2009 Samtools 2009 Annovar 2010 polyphen2 2013 SIFT 2009 dbSNP Exome Varian Server (EVS) 2014 SRX1161831 Whole exome sequencing of ovarian dysgenesis female 17595 SRP062710 PRJNA293547 Genomic DNA was extracted from peripheral blood using a homemade DNA extraction kit based on the "salting-out" method, and dissolved in low TE (1mM Tris-Hcl pH=8, 0.1mM EDTA). DNA quality and quantity was assessed using a Nanodrop Spectrophotometer and agarose gel electrophoresis. Libraries prepared from genomic DNA were hybridized to biotinylated cRNA oligonucleotide baits from the SureSelect Human All Exon Kit (Agilent Technologies, Santa Clara, California). Each exome-enriched library was sequenced with 50bp paired-end reads on two lanes of an ABI SOLiD-3 plus analyzer. SRS1042719 SAMN04005823 WXS GENOMIC Hybrid Selection 85 0 Application Read Forward 1 1 Application Read Reverse 51 AB SOLiD 3 Plus System Burrows-Wheeler Aligner (BWA) February 2009 Samtools 2009 Annovar 2010 polyphen2 2013 SIFT 2009 dbSNP Exome Variant Server (EVS) 2014