SRX1522166 GSM2033117 SRP068229 SRS1240173 GSM2033117 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033117 GEO Accession GSM2033117 SRX1522167 GSM2033118 SRP068229 SRS1240172 GSM2033118 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033118 GEO Accession GSM2033118 SRX1522168 GSM2033119 SRP068229 SRS1240171 GSM2033119 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033119 GEO Accession GSM2033119 SRX1522169 GSM2033120 SRP068229 SRS1240170 GSM2033120 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033120 GEO Accession GSM2033120 SRX1522170 GSM2033121 SRP068229 SRS1240169 GSM2033121 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033121 GEO Accession GSM2033121 SRX1522171 GSM2033122 SRP068229 SRS1240165 GSM2033122 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA was isolated using the miRVanaTM miRNA isolation kit from Ambion (Cat# AM1560) according to the manufacturer’s instructions. RNA sample quality control was performed by Exiqon (Vedbaek, Denmark). Library quality control and quantification were performed by Exiqon (Vedbaek, Denmark). The library preparation was done using TruSeq® Stranded mRNA Sample preparation kit (Illumina inc). The starting material (500 ng) of total RNA was mRNA enriched using the oligodT bead system (manufacturer). The isolated mRNA was subsequently fragmented using enzymatic fragmentation. Then first strand synthesis and second strand synthesis were performed and the double stranded cDNA was purified (AMPure XP, Beckman Coulter). The cDNA was end repaired, 3’ adenylated and Illumina sequencing adaptors ligated onto the fragments ends, and the library was purified (AMPure XP). The mRNA stranded libraries were pre-amplified with PCR and purified (AMPure XP). The libraries size distribution was validated and quality inspected on a Bioanalyzer high sensitivity DNA chip (Agilent Technologies). High quality libraries were quantified using qPCR, the concentration normalized and the samples pooled according to the project specification (number of reads). The library pool(s) were re-quantified with qPCR and optimal concentration of the library pool used to generate the clusters on the surface of a flowcell before sequencing on Nextseq500 instrument using High Output sequencing kit (50 cycles) according to the manufacturer instructions (Illumina Inc.). NextSeq 500 gds 302033122 GEO Accession GSM2033122