SRX1525622 Mm_A1_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A1_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525623 Mm_A1_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A1_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525624 Mm_B3_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B3_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525625 Mm_B3_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B3_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525626 Mm_C1_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C1_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525627 Mm_C1_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C1_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525628 Mm_C2_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C2_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525629 Mm_C2_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C2_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525630 Mm_C3_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C3_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525631 Mm_C3_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from mantle tissues of healthy clams without QPX infection. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (C1, C2 and C3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_C3_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525632 Mm_A2_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A2_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525633 Mm_A2_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A2_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525634 Mm_A3_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A3_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525635 Mm_A3_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from nodule tissues (QPX infection foci) of diseased clams. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (A1, A2 and A3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_A3_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525636 Mm_B1_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B1_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525637 Mm_B1_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B1_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525638 Mm_B2_R1 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B2_R1 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000 SRX1525639 Mm_B2_R2 SRP068241 PRJNA307120 Total RNA were extracted using Trizol following manufacturer's instruction from healthy (non-nodule) tissues of same diseased clams where nodule tissues were sampled. RNA were further cleaned-up (Rneasy Kits) and quantified (Nanodrop). RNA aliquot of 3 µg per sample was used and pooled (3 clams per pool) into a total of 3 pools (B1, B2 and B3). Each pool were then sequenced as a paired end (PE) reads library (100 pb) on the Illumina HiSeq 2000 platform. SRS1243554 SAMN04370755 Mm_B2_R2 RNA-Seq TRANSCRIPTOMIC RANDOM 200 0 Application Read Forward 1 1 Application Read Reverse 101 Illumina HiSeq 2000