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    <TITLE>GSM2648116: T47D xenografts_RNA-seq_Vehicle-rep1; Homo sapiens; RNA-Seq</TITLE>
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    <TITLE>GSM2648117: T47D xenografts_RNA-seq_EC313; Homo sapiens; RNA-Seq</TITLE>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <TITLE>GSM2648118: T47D xenografts_RNA-seq_EC313+Tamoxifen; Homo sapiens; RNA-Seq</TITLE>
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    <TITLE>GSM2648119: T47D xenografts_RNA-seq_Progesterone; Homo sapiens; RNA-Seq</TITLE>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
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        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
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    <TITLE>GSM2648125: T47D xenografts_RNA-seq_R5020+Tamoxifen; Homo sapiens; RNA-Seq</TITLE>
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        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648125</ID>
          <LABEL>GSM2648125</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648125</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648126" accession="SRX2880447">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880447</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648126</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648126: T47D xenografts_RNA-seq_EC313+BZA; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248338">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248338</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189700</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648126</ID>
          <LABEL>GSM2648126</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648126</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648127" accession="SRX2880448">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880448</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648127</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648127: T47D xenografts_RNA-seq_EC313+Raloxifene; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248339">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248339</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189699</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648127</ID>
          <LABEL>GSM2648127</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648127</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648128" accession="SRX2880449">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880449</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648128</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648128: T47D xenografts_RNA-seq_EC313+ICI; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248340">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248340</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189698</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648128</ID>
          <LABEL>GSM2648128</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648128</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648129" accession="SRX2880450">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880450</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648129</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648129: T47D xenografts_RNA-seq_Tamoxifen-rep2; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248342">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248342</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189697</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648129</ID>
          <LABEL>GSM2648129</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648129</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648130" accession="SRX2880451">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880451</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648130</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648130: T47D xenografts_RNA-seq_4124+Tamoxifen; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248341">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248341</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189696</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648130</ID>
          <LABEL>GSM2648130</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648130</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648131" accession="SRX2880452">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880452</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648131</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648131: T47D xenografts_RNA-seq_CDB4124; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248343">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248343</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189695</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648131</ID>
          <LABEL>GSM2648131</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648131</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2648132" accession="SRX2880453">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX2880453</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2648132</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2648132: T47D xenografts_RNA-seq_Control-rep2; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP074150" refname="GSE80619">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP074150</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2248344">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2248344</PRIMARY_ID>
          <EXTERNAL_ID namespace="BioSample">SAMN07189694</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <SINGLE/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Frozen xenograft tumors were finely grinded using cold hammer and a pestle. The pestle was placed over dry ice to maintain it at low temperatures. The ground tumor was suspended in ice-cold PBS and dounce homogenized and subsequently washed twice with ice-cold PBS. The cell pellets obtained from and washed xenografts were processed similar to the pellets obtained from in-vitro experiments (RNA-seq protocol). Hormone-treated cells were homogenized and total RNA was extracted using Qiagen RNAeasy kit. PolyA tail selection was performed on 250 ng of total RNA. RNA-seq libraries were prepared using NEBNext kit. Details of library preparation strategy are provided in the materials and methods section (RNA expression and RNA-sequencing) of the paper.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302648132</ID>
          <LABEL>GSM2648132</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2648132</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
