SRX1774255 GSM2159739 SRP075380 SRS1445992 GSM2159739 miRNA-Seq TRANSCRIPTOMIC size fractionation Total RNA were isolated from mouse tissue biopsies or from the samples obtained after AGO2 co-immunoprecipitation using the RNA NOW kit (Ozyme), with overnight precipitation so as to guarantee a maximum yield of small RNA. Bovine total RNA were prepared from about 50 mg mammary tissue using the Nucleospin® miRNA isolation kit (Macherey-Nagel Inc.) according to the manufacturer’s instructions. Both mouse and bovine samples were precipitated using sodium acetate 3M, 96% ethanol and 5 mg/mL glycogen. Libraries were prepared using the Illumina small RNA kit (Illumina) from GATC Biotech Company, according to the manufacturer’s instructions. Illumina HiSeq 2000 gds 302159739 GEO Accession GSM2159739 SRX1774256 GSM2159740 SRP075380 SRS1445994 GSM2159740 miRNA-Seq TRANSCRIPTOMIC size fractionation Total RNA were isolated from mouse tissue biopsies or from the samples obtained after AGO2 co-immunoprecipitation using the RNA NOW kit (Ozyme), with overnight precipitation so as to guarantee a maximum yield of small RNA. Bovine total RNA were prepared from about 50 mg mammary tissue using the Nucleospin® miRNA isolation kit (Macherey-Nagel Inc.) according to the manufacturer’s instructions. Both mouse and bovine samples were precipitated using sodium acetate 3M, 96% ethanol and 5 mg/mL glycogen. Libraries were prepared using the Illumina small RNA kit (Illumina) from GATC Biotech Company, according to the manufacturer’s instructions. Illumina HiSeq 2000 gds 302159740 GEO Accession GSM2159740