SRX1844443 GSM2199847 SRP076543 SRS1503296 GSM2199847 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199847 GEO Accession GSM2199847 SRX1844444 GSM2199848 SRP076543 SRS1503297 GSM2199848 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199848 GEO Accession GSM2199848 SRX1844445 GSM2199849 SRP076543 SRS1503298 GSM2199849 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199849 GEO Accession GSM2199849 SRX1844446 GSM2199850 SRP076543 SRS1503299 GSM2199850 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199850 GEO Accession GSM2199850 SRX1844447 GSM2199851 SRP076543 SRS1503300 GSM2199851 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199851 GEO Accession GSM2199851 SRX1844448 GSM2199852 SRP076543 SRS1503301 GSM2199852 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199852 GEO Accession GSM2199852 SRX1844449 GSM2199853 SRP076543 SRS1503302 GSM2199853 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199853 GEO Accession GSM2199853 SRX1844450 GSM2199854 SRP076543 SRS1503303 GSM2199854 RNA-Seq TRANSCRIPTOMIC cDNA Total RNA extraction was performed using Trizol (Invitrogen). RNA-seq library was generated using the Illumina TruSeq method according to the manufacturer’s instructions. Libraries were prepared for multiplex sequencing using Illumina TruSeq RNA sample prep kit v2, according to the manufacturer’s protocol. TruSeq universal adapter sequence is 5’-AATGATACGGCGACCACCGAGATCTACACTCTTTCCCTACACGACGCTCTTCCGATCT-3'. TruSeq adapter sequences for each sample are following: 1) WT_CD_1: 5’- GATCGGAAGAGCACACGTCTGAACTCCAGTCACCAGATCATCTCGTATGCCGTCTTCTGCTTG-3'; 2) WT_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCTTGTAATCTCGTATGCCGTCTTCTGCTTG-3'; 3) WT_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCGATGTATCTCGTATGCCGTCTTCTGCTTG-3'; 4) WT_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACTGACCAATCTCGTATGCCGTCTTCTGCTTG-3'; 5) KO_CD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACAGTCAAATCTCGTATGCCGTCTTCTGCTTG-3'; 6) KO_CD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACCCGTCCATCTCGTATGCCGTCTTCTGCTTG-3'; 7) KO_HFD_1: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACACAGTGATCTCGTATGCCGTCTTCTGCTTG-3'; 8) KO_HFD_2: 5’-GATCGGAAGAGCACACGTCTGAACTCCAGTCACGCCAATATCTCGTATGCCGTCTTCTGCTTG-3' Illumina HiSeq 2500 gds 302199854 GEO Accession GSM2199854