SRX1890827 shControl-Dox R1 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533812 SAMN05302431 shControl-Dox R1 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890828 shControl-Dox R2 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533813 SAMN05302432 shControl-Dox R2 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890829 shADAM12+Dox R2 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533814 SAMN05302441 shADAM12+Dox R2 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890830 shADAM12+Dox R3 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533815 SAMN05302442 shADAM12+Dox R3 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890831 shControl-Dox R3 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533816 SAMN05302433 shControl-Dox R3 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890832 shControl+Dox R1 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533817 SAMN05302434 shControl+Dox R1 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890833 shControl+Dox R2 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533818 SAMN05302435 shControl+Dox R2 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890834 shControl+Dox R3 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533819 SAMN05302436 shControl+Dox R3 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890835 shADAM12-Dox R1 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533820 SAMN05302437 shADAM12-Dox R1 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890836 shADAM12-Dox R2 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533821 SAMN05302438 shADAM12-Dox R2 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890837 shADAM12-Dox R3 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533822 SAMN05302439 shADAM12-Dox R3 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500 SRX1890838 shADAM12+Dox R1 SRP077683 PRJNA327112 Total RNA was isolated from shControl and shADAM12 SUM159PT cells ± doxycycline (n=3 for each condition) using the Qiagen RNeasy purification kit and on-column DNase I digestion according to the manufacturerÕs protocols. An NGS library was generated for each RNA sample using the Illumina TruSeq Library Prep kit. SRS1533823 SAMN05302440 shADAM12+Dox R1 RNA-Seq TRANSCRIPTOMIC RT-PCR Illumina HiSeq 2500