SRP095096 PRJNA357375 GSE92377 bulk cell RNA-seq of Lgr5+ ISCs with in vivo Rspo GOF and LOF sorted Lgr5-eGFP+ cells under conditions of in vivo Rspo manipulation in reporter mice, Overall design: Ad Fc (control) vs Ad LGR5 ECD (LOF) vs Ad Rspo1 (GOF) treatment. Two biological replicates were used for Ad Fc and three biological replicates were used for LOF and GOF conditions GSE92377 pubmed 28467820