SRX2574445 GSM2495101 SRP100194 SRS1990214 GSM2495101 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495101 GEO Accession GSM2495101 SRX2574446 GSM2495102 SRP100194 SRS1990215 GSM2495102 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495102 GEO Accession GSM2495102 SRX2574447 GSM2495103 SRP100194 SRS1990216 GSM2495103 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495103 GEO Accession GSM2495103 SRX2574448 GSM2495104 SRP100194 SRS1990217 GSM2495104 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495104 GEO Accession GSM2495104 SRX2574449 GSM2495105 SRP100194 SRS1990218 GSM2495105 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495105 GEO Accession GSM2495105 SRX2574450 GSM2495106 SRP100194 SRS1990219 GSM2495106 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495106 GEO Accession GSM2495106 SRX2574451 GSM2495107 SRP100194 SRS1990220 GSM2495107 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495107 GEO Accession GSM2495107 SRX2574452 GSM2495108 SRP100194 SRS1990221 GSM2495108 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495108 GEO Accession GSM2495108 SRX2574453 GSM2495109 SRP100194 SRS1990222 GSM2495109 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495109 GEO Accession GSM2495109 SRX2574454 GSM2495110 SRP100194 SRS1990223 GSM2495110 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495110 GEO Accession GSM2495110 SRX2574455 GSM2495111 SRP100194 SRS1990224 GSM2495111 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495111 GEO Accession GSM2495111 SRX2574456 GSM2495112 SRP100194 SRS1990225 GSM2495112 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495112 GEO Accession GSM2495112 SRX2574457 GSM2495113 SRP100194 SRS1990226 GSM2495113 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495113 GEO Accession GSM2495113 SRX2574458 GSM2495114 SRP100194 SRS1990227 GSM2495114 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495114 GEO Accession GSM2495114 SRX2574459 GSM2495115 SRP100194 SRS1990228 GSM2495115 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495115 GEO Accession GSM2495115 SRX2574460 GSM2495116 SRP100194 SRS1990229 GSM2495116 RNA-Seq TRANSCRIPTOMIC cDNA RNA was purified from 2x15uM scrolls from each FFPE block using the Agencourt FormaPure kit (Beckman Coulter) using a BioMek 4000 Automated Liquid Handling System (Beckman Coulter). For fresh-frozen control meninges samples, RNA was purified using Trizol (Invitrogen). Samples with high molecular weight material based on QC on an Fragment Analyzer (Advanced Analytical) were treated with RapidOUT DNase (ThermoFisher Scientific). Ribosomal RNA was subtracted by hybridization from 1-2.5ug total RNA per sample using the RiboZero Magnetic Gold HMR Kit (Illumina). Directional RNA-seq libraries were prepared from 50-100 ug rRNA-depleted RNA using the NEBNext Ultra Directional RNA Library Prep Kit for Illumina (New England Biolabs). Illumina HiSeq 2500 gds 302495116 GEO Accession GSM2495116