SRX2880723 NPC_3m6_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248585 NPC_3m6_RNA NPC_3m6_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880724 NPC_12m5_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248586 NPC_12m5_RNA NPC_12m5_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880725 Cereb_12m2_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248587 Cereb_12m2_RNA Cereb_12m2_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880726 Cereb_12m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248588 Cereb_12m3_RNA Cereb_12m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880727 Cereb_3m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248589 Cereb_3m3_RNA Cereb_3m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880728 Cereb_12m1_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248590 Cereb_12m1_RNA Cereb_12m1_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880729 Cereb_29m4_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248591 Cereb_29m4_RNA Cereb_29m4_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880730 NPC_3m5_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248592 NPC_3m5_RNA NPC_3m5_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880731 Cereb_29m2_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248593 Cereb_29m2_RNA Cereb_29m2_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880732 Cereb_29m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248594 Cereb_29m3_RNA Cereb_29m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880733 OB_29m4_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248595 OB_29m4_RNA OB_29m4_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880734 OB_12m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248596 OB_12m3_RNA OB_12m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880735 OB_12m1_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248597 OB_12m1_RNA OB_12m1_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880736 3m4_heart_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248598 3m4_heart_RNA 3m4_heart_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880737 3m3_Liver_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248599 3m3_Liver_RNA 3m3_Liver_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880738 3m2_Liver_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248600 3m2_Liver_RNA 3m2_Liver_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880739 3m1_Liver_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248601 3m1_Liver_RNA 3m1_Liver_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880740 12m2_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248602 12m2_LiverRNA 12m2_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880741 12m1_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248603 12m1_LiverRNA 12m1_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880742 3m6_heart_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248604 3m6_heart_RNA 3m6_heart_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880743 3m5_heart_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248605 3m5_heart_RNA 3m5_heart_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880744 12m4_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248606 12m4_heartRNA 12m4_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880745 12m3_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248607 12m3_LiverRNA 12m3_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880746 29m6_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248608 29m6_heartRNA 29m6_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880747 29m5_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248609 29m5_heartRNA 29m5_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880748 29m4_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248610 29m4_heartRNA 29m4_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880749 29m3_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248611 29m3_LiverRNA 29m3_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880750 29m2_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248612 29m2_LiverRNA 29m2_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880751 29m1_LiverRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248613 29m1_LiverRNA 29m1_LiverRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880752 12m6_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248614 12m6_heartRNA 12m6_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880753 12m5_heartRNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248615 12m5_heartRNA 12m5_heartRNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880754 NPC_29m5_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248616 NPC_29m5_RNA NPC_29m5_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880755 NPC_12m6_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248617 NPC_12m6_RNA NPC_12m6_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880756 OB_3m1_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248618 OB_3m1_RNA OB_3m1_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880757 NPC_29m6_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248619 NPC_29m6_RNA NPC_29m6_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880758 OB_3m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248620 OB_3m3_RNA OB_3m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880759 OB_3m2_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248621 OB_3m2_RNA OB_3m2_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880760 Cereb_3m2_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248622 Cereb_3m2_RNA Cereb_3m2_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880761 Cereb_3m1_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248623 Cereb_3m1_RNA Cereb_3m1_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880762 OB_29m3_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248624 OB_29m3_RNA OB_29m3_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500 SRX2880763 OB_29m2_RNA SRP057387 PRJNA281127 All tissue and cell samples were flash-frozen in liquid nitrogen until further processing. RNA was isolated using RNAeasy plus mini kit (Qiagen). 1ug of total RNA was combined to 2uL of a 1:100 dilution of ERCC RNA Spike in mix (Thermo-Fisher scientific) in nuclease-free water. The resulting mix was then subjected to rRNA depletion using the NEBNext rRNA Depletion Kit (New England Bioloabs). Strand specific RNA-seq libraries were then constructed using the SMARTer® Stranded RNA-Seq Kit (Clontech # 634836), according to the manufacturer’s protocol. Paired-end 75bp reads were generated on the Illumina NetxSeq 500 platform. SRS2248626 OB_29m2_RNA OB_29m2_RNA RNA-Seq TRANSCRIPTOMIC cDNA NextSeq 500