<?xml version="1.0" encoding="UTF-8"?>
<EXPERIMENT_SET xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <EXPERIMENT alias="GSM2787575" accession="SRX3197484">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197484</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787575</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787575: Input plasmid library, replicate #1; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524563">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524563</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787575</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787575</ID>
          <LABEL>GSM2787575</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787575</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787576" accession="SRX3197485">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197485</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787576</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787576: Input plasmid library, replicate #2; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524564">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524564</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787576</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787576</ID>
          <LABEL>GSM2787576</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787576</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787577" accession="SRX3197486">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197486</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787577</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787577: Input plasmid library, replicate #3; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524565">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524565</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787577</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787577</ID>
          <LABEL>GSM2787577</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787577</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787578" accession="SRX3197487">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197487</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787578</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787578: Input plasmid library, replicate #4; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524567">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524567</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787578</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787578</ID>
          <LABEL>GSM2787578</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787578</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787579" accession="SRX3197488">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197488</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787579</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787579: Input plasmid library, replicate #5; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524566">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524566</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787579</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787579</ID>
          <LABEL>GSM2787579</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787579</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787580" accession="SRX3197489">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197489</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787580</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787580: Output RNA, replicate #1; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524568">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524568</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787580</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>RNA was collected using the Qiagen RNEasy Maxi kit following manufacturer's instructions and performing the optional on-column Dnase treatment. PolyA+ RNA was extracted using the Oligotex mRNA Midi kit. We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787580</ID>
          <LABEL>GSM2787580</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787580</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787581" accession="SRX3197490">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197490</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787581</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787581: Output RNA, replicate #2; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524569">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524569</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787581</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>RNA was collected using the Qiagen RNEasy Maxi kit following manufacturer's instructions and performing the optional on-column Dnase treatment. PolyA+ RNA was extracted using the Oligotex mRNA Midi kit. We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787581</ID>
          <LABEL>GSM2787581</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787581</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787582" accession="SRX3197491">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197491</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787582</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787582: Output RNA, replicate #3; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524571">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524571</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787582</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>RNA was collected using the Qiagen RNEasy Maxi kit following manufacturer's instructions and performing the optional on-column Dnase treatment. PolyA+ RNA was extracted using the Oligotex mRNA Midi kit. We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787582</ID>
          <LABEL>GSM2787582</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787582</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787583" accession="SRX3197492">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197492</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787583</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787583: Output RNA, replicate #4; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524570">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524570</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787583</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>RNA was collected using the Qiagen RNEasy Maxi kit following manufacturer's instructions and performing the optional on-column Dnase treatment. PolyA+ RNA was extracted using the Oligotex mRNA Midi kit. We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787583</ID>
          <LABEL>GSM2787583</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787583</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787584" accession="SRX3197493">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197493</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787584</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787584: Output RNA, replicate #5; Homo sapiens; RNA-Seq</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524572">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524572</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787584</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>RNA-Seq</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>TRANSCRIPTOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>cDNA</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>RNA was collected using the Qiagen RNEasy Maxi kit following manufacturer's instructions and performing the optional on-column Dnase treatment. PolyA+ RNA was extracted using the Oligotex mRNA Midi kit. We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>NextSeq 500</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787584</ID>
          <LABEL>GSM2787584</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787584</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
  <EXPERIMENT alias="GSM2787585" accession="SRX3197494">
    <IDENTIFIERS>
      <PRIMARY_ID>SRX3197494</PRIMARY_ID>
      <SUBMITTER_ID namespace="GEO">GSM2787585</SUBMITTER_ID>
    </IDENTIFIERS>
    <TITLE>GSM2787585: Long-read sequencing for plasmid library; Homo sapiens; OTHER</TITLE>
    <STUDY_REF accession="SRP118092" refname="GSE104001">
      <IDENTIFIERS>
        <PRIMARY_ID>SRP118092</PRIMARY_ID>
      </IDENTIFIERS>
    </STUDY_REF>
    <DESIGN>
      <DESIGN_DESCRIPTION/>
      <SAMPLE_DESCRIPTOR accession="SRS2524573">
        <IDENTIFIERS>
          <PRIMARY_ID>SRS2524573</PRIMARY_ID>
          <EXTERNAL_ID namespace="GEO">GSM2787585</EXTERNAL_ID>
        </IDENTIFIERS>
      </SAMPLE_DESCRIPTOR>
      <LIBRARY_DESCRIPTOR>
        <LIBRARY_STRATEGY>OTHER</LIBRARY_STRATEGY>
        <LIBRARY_SOURCE>GENOMIC</LIBRARY_SOURCE>
        <LIBRARY_SELECTION>other</LIBRARY_SELECTION>
        <LIBRARY_LAYOUT>
          <PAIRED/>
        </LIBRARY_LAYOUT>
        <LIBRARY_CONSTRUCTION_PROTOCOL>Plasmid DNA was extracted from MegaX DH10B electrocompetent bacteria transformed with cloned library using Qiagen's Plasmid Plus MegaPrep Kit following manufacturer's instructions We used a custom library construction protocol, see Methods section in paper for detailed protocol. Briefly, for RNA, following PolyA+ selection we performed reverse transcription using a sgGFP reporter gene-specific primer and performed PCR to add barcoded Illumina sequencing adapters. For plasmid reporter library, we directly performed PCR to add sequencing adapters off of the plasmid.</LIBRARY_CONSTRUCTION_PROTOCOL>
      </LIBRARY_DESCRIPTOR>
    </DESIGN>
    <PLATFORM>
      <ILLUMINA>
        <INSTRUMENT_MODEL>Illumina MiSeq</INSTRUMENT_MODEL>
      </ILLUMINA>
    </PLATFORM>
    <EXPERIMENT_LINKS>
      <EXPERIMENT_LINK>
        <XREF_LINK>
          <DB>gds</DB>
          <ID>302787585</ID>
          <LABEL>GSM2787585</LABEL>
        </XREF_LINK>
      </EXPERIMENT_LINK>
    </EXPERIMENT_LINKS>
    <EXPERIMENT_ATTRIBUTES>
      <EXPERIMENT_ATTRIBUTE>
        <TAG>GEO Accession</TAG>
        <VALUE>GSM2787585</VALUE>
      </EXPERIMENT_ATTRIBUTE>
    </EXPERIMENT_ATTRIBUTES>
  </EXPERIMENT>
</EXPERIMENT_SET>
